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GlossaryCytotoxicity (Cytotoxic Effects)

quality of being toxic to cells, often used in cancer treatment

Cytotoxicity refers to the quality of being toxic to cells. It describes the ability of certain substances or treatments, such as chemotherapy drugs, to kill or damage cells. This property is crucial in cancer treatment, where the goal is to target and destroy cancerous cells while minimizing harm to healthy cells.

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Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

88 citations, February 2008 in “Journal of Medicinal Chemistry”

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

research HaCaT Cell Proliferation Influenced by Melatonin

28 citations, January 2003 in “Skin pharmacology and physiology”

Melatonin affects skin cell growth differently based on how much and how long it's used.

research Cytostatics and Immunosuppressive Drugs: Toxicities and Management

January 1989 in “Side effects of drugs annual”

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

research Possible Role of Autophagy Activation in Stimulation of Regeneration

September 2013 in “Molecular Biology”

The document suggests that activating autophagy might help with regeneration by removing old and damaged cells.

research Leucoderma Associated With the Use of Topical Minoxidil: A Report of Two Cases

15 citations, January 2000 in “Dermatology”

Minoxidil use may cause skin pigmentation loss.

research Hydrogen Peroxide (H2O2) Suppresses Hair Growth Through Downregulation of Beta-Catenin

13 citations, September 2017 in “Journal of Dermatological Science”

Hydrogen peroxide in hair dye can cause hair loss.

research Updates in the Pathogenesis of Alopecia Areata

April 2021 in “Sohag Medical Journal”

Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.

research Mild Oxidative Stress Protects Against Chemotherapy-Induced Hair Loss

2 citations, January 2023 in “Frontiers in Oncology”

Mild oxidative stress can prevent hair loss from chemotherapy.

research Permanent Alopecia in Breast Cancer Patients: Role of Taxanes and Endocrine Therapies

2 citations, March 2021 in “Cutis”

Some breast cancer treatments, like taxanes, can cause long-term hair loss.

research Potential Pharmacological Activities of Pumpkin Seeds as a Functional Food: A Comprehensive Review

June 2023 in “Journal of Ayurvedic and herbal medicine”

Pumpkin seeds may improve health due to their rich nutrients and potential to treat various conditions.

research Malignancy and Cancer Treatment-Related Hair and Nail Changes

43 citations, November 2007 in “Dermatologic Clinics”

Hair and nail changes can indicate health issues, including cancer and side effects from cancer treatments.

Immunohistopathological Analysis of Frizzled-4-Positive Immature Melanocytes from Hair Follicles of Patients with Rhododenol-Induced Leukoderma

research Immunohistopathological Analysis of Frizzled-4-Positive Immature Melanocytes from Hair Follicles of Patients with Rhododenol-Induced Leukoderma

8 citations, August 2015 in “Journal of dermatological science”

Rhododendrol in skin-whitening products can cause skin depigmentation and immune reactions.

research Cytotoxic Activity Test of Ethanol and Methanol Extracts of Spirulina Platensis L. on WiDr Cells

February 2019

Ethanol and methanol extracts of Spirulina platensis do not kill WiDr colon cancer cells.

Multiple Readout Assay for Hormonal (Androgenic and Antiandrogenic) and Cytotoxic Activity of Plant and Fungal Extracts Based on Differential Prostate Cancer Cell Line Behavior

research Multiple Readout Assay for Hormonal (Androgenic and Antiandrogenic) and Cytotoxic Activity of Plant and Fungal Extracts Based on Differential Prostate Cancer Cell Line Behavior

19 citations, August 2014 in “Journal of Ethnopharmacology”

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

Proposition of a Low-Cost Field Assay to Determine Antiproliferative Properties of Indigenous Plants Using Dugesia Dorotocephala (Brown Planaria)

research Proposition of a Low-Cost Field Assay to Determine Antiproliferative Properties of Indigenous Plants Using Dugesia Dorotocephala (Brown Planaria)

3 citations, February 2015 in “Scientific Research and Essays”

The study showed that brown planaria can be used to cheaply test if local plants can stop cell growth.

research Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer

61 citations, April 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Docetaxel and paclitaxel for breast cancer can cause permanent, severe hair loss.

research Influence of Melatonin on HaCaT Cell Proliferation Measured by Means of ATP Bioluminescence and Fluorometric Assays

November 2002

Melatonin affects cell growth differently based on its concentration.

research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes

34 citations, January 1997 in “Skin Pharmacology and Physiology”

Minoxidil affects cell growth in two ways: low doses increase growth, while high doses slow it down and can be toxic.

research Hair Growth Promoting Effect of Thuja Orientalis Ethanol Extracts on Hair Loss-Induced DBA1J Mice

1 citations, January 2004 in “Journal of Physiology & Pathology in Korean Medicine”

Thuja orientalis extract significantly promotes hair growth in mice with hair loss.

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

1 citations, February 2023 in “Plants”

BB4CMU rice bran oil may help treat hair loss and gray hair.

research Effect of Ethanolic Propolis Extract from Tetragonula Biroi Bees on the Growth of Human Cancer Cell Lines HeLa and MCF-7

12 citations, January 2019 in “AIP conference proceedings”

Propolis from Tetragonula biroi bees may help fight cancer cells.

research Designed, Synthesis, In Vitro and Computational Analyses of Anticancer Nicotinamide Derivatives

February 2024 in “Indian Journal of Chemistry”

Compound N4 effectively kills breast cancer cells and compounds N2 and N3 have strong antibacterial and antifungal properties.

Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

research Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

1 citations, October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products”

Ficus carica leaf extract may help treat melanoma by promoting cancer cell death without harming normal cells.

The Effect of Active Hexose Correlated Compound in Modulating Cytosine Arabinoside-Induced Hair Loss, and 6-Mercaptopurine- and Methotrexate-Induced Liver Injury in Rodents

research The Effect of Active Hexose Correlated Compound in Modulating Cytosine Arabinoside-Induced Hair Loss, and 6-Mercaptopurine- and Methotrexate-Induced Liver Injury in Rodents

14 citations, August 2009 in “Cancer epidemiology”

AHCC reduces hair loss and liver injury caused by chemotherapy in rodents.

Anti-Androgen Effects of Extracts and Compounds from Ganoderma Lucidum

research The Effect of Topical RU58841 (Androgen Receptor Blocker) Combined with Minoxidil on Hair Growth in Macaque Androgenetic Alopecia

March 1998 in “Journal of Dermatological Science”

Combining RU58841 and minoxidil significantly increases hair growth.

research Effects of Allium Hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells

2 citations, May 2023 in “Plants”

Allium hookeri extract may help promote hair growth and protect cells from damage.

research Novel Synthesis of Nicotinamide Derivatives with Cytotoxic Properties

51 citations, March 2006 in “Bioorganic & Medicinal Chemistry”

Newly made nicotinamide compounds could potentially treat cancer.