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    Did you mean Central Centrifugal Cicatricial Alopecia?
    Glossary Central Centrifugal Cicatricial Alopecia

    scarring hair loss starting at the scalp's crown, common in African American women

    Central Centrifugal Cicatricial Alopecia (CCCA) is a type of scarring hair loss that typically starts at the crown of the scalp and spreads outward in a circular pattern. It is most commonly seen in African American women and can lead to permanent hair loss due to the destruction of hair follicles and subsequent scarring.

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    1. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    2. Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans Veterinary pathology · 2010 · 56 citations
    3. Central centrifugal cicatricial alopecia: challenges and solutions Clinical, Cosmetic and Investigational Dermatology · 2016 · 37 citations
    4. Central centrifugal cicatricial alopecia – an approach to diagnosis and management International Journal of Dermatology · 2011 · 32 citations
    5. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 25 citations
    6. Central centrifugal cicatricial alopecia Indian Dermatology Online Journal · 2013 · 11 citations
    7. Transitory hair growth using platelet‐rich plasma therapy in stabilized central centrifugal cicatricial alopecia Dermatologic therapy · 2022 · 6 citations
    8. Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation JID Innovations · 2024 · 5 citations
    9. Central Centrifugal Cicatricial Alopecia in the Adolescent Population: An Overview of Available Literature Life · 2023 · 5 citations
    10. Central centrifugal cicatricial alopecia in Black men: A case series highlighting key clinical features in this cohort JAAD Case Reports · 2023 · 2 citations
    11. Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia JID innovations · 2021 · 2 citations
    12. Differentiating central centrifugal cicatricial alopecia and androgenetic alopecia in african american men: report of three cases. PubMed · 2012 · 2 citations
    13. Adjuvant use of topical metformin with standard therapies in recalcitrant central centrifugal cicatricial alopecia: A case series JAAD Case Reports · 2025 · 2 citations
    14. Quantification of mast cells in central centrifugal cicatricial alopecia JAAD International · 2023 · 1 citations
    15. Preservation of sebaceous glands and peroxisome proliferator-activated receptor gamma expression in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 1 citations
    16. Central Centrifugal Cicatricial Alopecia Updates in clinical dermatology · 2026
    17. Central Centrifugal Cicatricial Alopecia: A Survey of Treatment Practices Among Dermatology Residents and Attending Physicians Cureus · 2025
    18. Topical Ruxolitinib in Combination with Oral Minoxidil Results in Hair Regrowth in a Patient with Central Centrifugal Cicatricial Alopecia and Concomitant Traction Alopecia JAAD Case Reports · 2025
    19. Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia JAMA Dermatology · 2024
    20. Central Centrifugal Cicatricial Alopecia (CCCA): Unraveling the Complexities of a Scarring Hair Disorder International journal of medical science and clinical research studies · 2024
    21. Enlarging alopecic patch in an African American woman with central centrifugal cicatricial alopecia: A case of concomitant tinea incognito JAAD case reports · 2022
    22. 863 Central centrifugal cicatricial alopecia gene expression analysis revealed cholesterol, fatty acid, and mast cell pathways 2019
    23. Dermatoscopic features of central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2014 · 64 citations
    24. Hair Transplantation in the Surgical Treatment of Central Centrifugal Cicatricial Alopecia Dermatologic Surgery · 2014 · 25 citations
    25. The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review. PubMed · 2020 · 3 citations
    26. A retrospective clinical and laboratory analysis including vitamin D and antinuclear antibodies in central centrifugal cicatricial alopecia and nonscarring alopecia in African Americans Journal of the American Academy of Dermatology · 2024 · 2 citations
    27. Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment Clinical, cosmetic and investigational dermatology · 2022 · 2 citations
    28. Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis Acta Dermato Venereologica · 2026
    29. Patchy presentation of central centrifugal cicatricial alopecia Dermatology Online Journal · 2026
    30. Three Types of Alopecia in One Patient: A Case of Central Centrifugal Cicatricial Alopecia, Alopecia Areata, and Telogen Effluvium JAAD Case Reports · 2025