Neutrophil Elastase Is Critical In Linear IgA Bullous Dermatosis In Mice
April 2023
in “
Journal of Investigative Dermatology
”
neutrophil elastase linear IgA bullous dermatosis Primer Cicatricial Alopecias scarring alopecia hair follicle CD8+ T cells epithelial hair follicle stem cells fibrosis CD200R CD200-CD200R signaling pathway immune privilege LPP CCCA DLE scarring hair loss hair follicle stem cells immune system attack lichen planopilaris central centrifugal cicatricial alopecia discoid lupus erythematosus
TLDR CD8+ T cells attack hair follicle stem cells, causing scarring and hair loss.
This study investigates the role of immune mechanisms in Primer Cicatricial Alopecias (PCAs), which are characterized by irreversible hair loss due to scarring of the hair follicle. Researchers developed a mouse model of alopecia with skin fibrosis by transferring OT1 T cells into autoimmune-prone mice. They found that CD8+ T cells attack epithelial hair follicle stem cells, leading to fibrosis and hair loss. The study highlights a significant reduction in CD200R expression in affected mouse skin, suggesting that the CD200-CD200R signaling pathway, known for its immunoregulatory role, may protect hair follicles from immune attack. The gene expression in this model showed similarities with human conditions like LPP, CCCA, and DLE. The research aims to further explore immune privilege breakdown in hair follicles to identify new treatment targets for scarring alopecia.
