8 citations
,
February 2014 in “General and Comparative Endocrinology” In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.
January 2010 in “CNR Solar (Scientific Open-access Literature Archive and Repository) (Consiglio Nazionale delle Ricerche)” This study found that combining metformin and clomifene citrate improved pregnancy outcomes and reduced miscarriage rates in women with PCOS and infertility undergoing intrauterine insemination.
1 citations
,
July 2023 in “F&S Reviews” This review highlights that various commonly prescribed medications for chronic conditions may impact male fertility by affecting hormone secretion, sperm production, ejaculation, erectile function, and libido, although conclusive evidence is limited to specific drug groups.
4 citations
,
January 2006 in “PubMed” This study found that finasteride-induced DHT deficiency altered estrogen receptor expression in the epididymis, potentially destabilizing its function.
May 2024 in “The journal of sexual medicine” This study on adult male rats found that finasteride treatment led to molecular changes linked to erectile dysfunction, while withdrawal from the drug did not alter these parameters.
May 2025 in “VETERINARY SCIENCE TECHNOLOGIES OF ANIMAL HUSBANDRY AND NATURE MANAGEMENT” In this study, researchers determined that poor feed quality and nutritional deficiency, especially low vitamin A levels, were leading causes of impaired reproductive function in nutria, with deficiencies most pronounced during February-March and linked to clinical signs like growth retardation and alopecia.
April 2022 in “International Journal of Science and Research (IJSR)” This study found a correlation between polycystic ovarian disease and infertility among women, with 72% of participants experiencing difficulty conceiving.
June 2021 in “Archives of Advances in Biosciences” This study suggests that finasteride at doses of 5 mg/kg BW or higher may adversely affect spermatogenesis and male fertility in NMRI mice.
37 citations
,
January 2009 in “Sexual Development” This study found that chronic exposure to fadrozole or finasteride during frog development induced intersex individuals, which displayed different gene expression profiles depending on the chemical used.
In this reported case, a male German Spitz diagnosed with alopecia X showed partial regrowth of alopecic areas after treatment with orchiectomy and melatonin, indicating this combination's potential effectiveness for the condition.
October 2010 in “Journal of Men's Health” This study found that adolescent men in Ireland are more likely to prefer keeping a baby over abortion in a hypothetical unplanned pregnancy, influenced by their anticipated regret and perceived familial attitudes.
18 citations
,
May 2002 in “BJUI” This study found that chronic exposure to finasteride did not significantly impact spermatogenesis in rats.
January 2022 in “European journal of anatomy” This study reports a rare case of polyorchidism in a 96-year-old male cadaver, suggesting a new classification based on anatomical and histological findings to aid in accurate diagnosis.
January 2025 in “LUMEN ET VIRTUS” In this study, a case of alopecia X in a male, uncastrated German Spitz dog was successfully managed with orchiectomy and melatonin, leading to partial hair regrowth and improved dermatological condition after 90 days of treatment.
April 2016 in “The Journal of Sexual Medicine” PFS affects some women, steroids easily bought online, hypogonadism info unreliable, low testosterone linked to CVD.
April 2023 in “Clinical theriogenology” This report highlights the usefulness of specific diagnostic procedures, including penile/preputial cytology and transabdominal ultrasonography, in diagnosing cryptorchidism and Sertoli cell tumors in dogs with generalized skin conditions.
February 2018 in “The Journal of Sexual Medicine” In this animal study, finasteride exposure led to impaired spermatogenesis in rats, while the novel compound DA-9401, derived from three medicinal herbs, demonstrated potential in improving sperm parameters and reducing testicular apoptosis when used alone or with finasteride.
3 citations
,
August 2004 in “International journal of gynaecology and obstetrics” Finasteride doesn't change polycystic ovary size or cyst number, suggesting testosterone's role in their appearance.
45 citations
,
June 1984 in “Journal of the American Veterinary Medical Association” In this study, zinc supplementation rapidly improved conditions such as anorexia, depression, and foot soreness in sheep and goats diagnosed with zinc deficiency, along with healing skin lesions and resumption of hair and wool growth.
In this systematic review, researchers observed that Toxoplasma gondii infection is associated with alterations in testosterone levels, generally increasing in humans but showing mixed effects in animals, highlighting a complex relationship that warrants further investigation.
January 2024 in “University of Zagreb University Computing Centre (SRCE)” In this retrospective study, researchers observed that infertile patients with PCOS have significantly different serum levels of certain hormones, specifically higher AMH and LH, and lower E2 and FSH, compared to infertile women without PCOS.
January 2025 in “American Journal of Translational Research” This study reported that the combination of EE-CPA and raloxifene effectively manages PCOS-related infertility, enhancing pregnancy outcomes through improvements in metabolism, sex hormones, ovarian function, and endometrial receptivity, without significantly increasing adverse effects.
January 2018 in “Elsevier eBooks” This review discusses the role of DHT in male sexual differentiation and fertility in individuals with 5α-reductase-2 deficiency, reporting no new clinical results.
70 citations
,
April 2014 in “Annales d'endocrinologie” This review discusses the pathways of androgen biosynthesis and reports no new findings, highlighting the need to understand the interplay between the classic and backdoor pathways.
2 citations
,
March 2016 in “The Journal of Urology” This study found that the 1 mg dose of finasteride was associated with a wide range of adverse effects, including sexual, psychological, and metabolic symptoms, in the FAERS data.
10 citations
,
July 2000 in “PubMed” This case report suggests that increased dietary calcium from alfalfa may have contributed to zinc deficiency in two adult female goats by blocking zinc absorption.
October 2017 in “Universidad Nacional de Trujillo” This study found that low doses of hydroethanolic extract from Coffea arabica L. seeds reduced prostatic growth in mice with induced prostatic hyperplasia, while both low and high doses lowered uric acid and PSA levels.
June 2018 in “The Journal of Sexual Medicine” This study used high-resolution ultrasound to investigate the pathophysiology of persistent erectile dysfunction in young men who used the drug finasteride, observing differences in erectile tissue homogeneity compared to control subjects without finasteride exposure.
1 citations
,
February 2018 in “The Journal of Sexual Medicine” This study found that young men with post-finasteride syndrome may experience erectile dysfunction due to potential histologic changes in penile tissue, despite having normal penile Doppler hemodynamics.
January 2004 in “Actualidad en farmacología y terapéutica” This study found that combination therapy with doxazosin and finasteride was more effective in preventing the clinical progression of benign prostatic hyperplasia than either drug alone.