Protective Effect of DA-9401 on Acute Use of Finasteride on Sprague-Dawley Rats
February 2018
in “
The Journal of Sexual Medicine
”
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Studysummary In this animal study, finasteride exposure led to impaired spermatogenesis in rats, while the novel compound DA-9401, derived from three medicinal herbs, demonstrated potential in improving sperm parameters and reducing testicular apoptosis when used alone or with finasteride. Our plain-language summary of this paper — not a Tressless recommendation.
The document contains summaries of various studies conducted on Sprague-Dawley rats to investigate the protective effect of DA-9401 on acute use of finasteride. The studies found that DA-9401 had a protective effect on hair loss, liver and kidney function, blood glucose levels, and the negative effects of finasteride on the rats' prostate and seminal vesicles. DA-9401 was also found to improve hormonal imbalance and prevent endoplasmic reticulum stress in the testes. The studies suggest that DA-9401 may be a potential treatment for hair loss caused by finasteride and infertility caused by finasteride use.
