174 citations
,
July 2003 in “The Journal of Clinical Endocrinology & Metabolism” This study investigated genetic and phenotypic characteristics of androgen insensitivity syndrome in individuals with a 46,XY karyotype, documenting a range from complete to partial insensitivity.
8 citations
,
January 2024 in “Journal of Human Reproductive Sciences” This study found that serum zinc levels were lower in PCOS subjects compared to normal controls, suggesting zinc may play a vital role in PCOS pathophysiology.
143 citations
,
August 1991 in “Endocrinology” This study found that blocking androgen receptors inhibits testicular descent in rats more effectively during the early stages of gubernacular outgrowth than inhibiting 5a-reductase.
1 citations
,
December 2005 in “The Journal of Urology” This editorial comment reports no new clinical findings, instead discussing a study on the effectiveness of combination therapy with doxazosin and finasteride in patients with benign prostatic hyperplasia.
73 citations
,
January 1994 in “European Urology” This study found that finasteride significantly reduced serum dihydrotestosterone levels, confirming its efficacy as a 5a-reductase inhibitor, while Permixon showed no effect in healthy male volunteers.
14 citations
,
March 2000 in “Journal of Zoo and Wildlife Medicine” This study identified a new Demodex species causing demodicosis in a zoo koala, successfully treated with daily oral ivermectin.
29 citations
,
February 2007 in “Hormone and metabolic research” This study found that antisense oligonucleotides can significantly reduce androgen receptor expression in cultured human sebocytes and may offer new therapeutic possibilities for androgen-associated skin diseases.
December 2023 in “Benha Journal of Applied Sciences” This study found that male patients with androgenetic alopecia had higher serum levels of Zinc Alpha 2 Glycoprotein than healthy controls, suggesting its potential role in the disease's pathophysiology.
20 citations
,
July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
August 2013 in “Fertility and Sterility” This in vitro study suggests that factors in the serum of PCOS patients may contribute to ovarian dysfunction, evidenced by higher hormone production and primordial follicle survival compared to control sera.
2 citations
,
May 2012 in “Indian drugs” This study found that a proniosomal gel formulation of finasteride increased anagen hair count in male volunteers with androgenic alopecia by 42.85% compared to the control group.
January 2008 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study found that the gene for the enzyme aromatase is expressed in scalp hair follicles of women and is negatively correlated with LH levels, potentially reflecting the hormonal environment of hair follicles in PCOS.
February 2023 in “Vaccines” This review discusses the potential impact of COVID-19 on the male reproductive system and highlights unanswered questions regarding its mechanisms and implications for men's health and fertility, reporting no new clinical results.
3 citations
,
May 2023 in “Biomedicines” This article reviews the immunometabolic mechanisms linking polycystic ovary syndrome to infertility and stresses the need for interdisciplinary approaches to treat PCOS-related fertility issues; it reports no new clinical results.
3 citations
,
June 1999 in “The Prostate” This study found that finasteride and its combination with terazosin significantly reduced PSA levels in patients with benign prostatic hyperplasia, whereas terazosin alone showed no clinically significant effect.
February 2006 in “Inpharma Weekly”
January 2021 in “Scholars journal of medical case reports” This case report details a 34-year-old woman's experience with infertility linked to PCOS, where surgical intervention and medication led to eventual pregnancy with complications.
1 citations
,
April 2018 in “Sleep” This study found that finasteride use was associated with significantly higher odds of obstructive sleep apnea and insomnia compared to other medications.
October 2024 in “Andrology” This study investigated paternal drug exposure using FDA data and identified significant associations with reproductive health risks, including congenital anomalies linked to immunosuppressive drugs, and emphasized specific risk combinations like biologics and abortion, diazepam and small for date baby, and finasteride and cryptorchidism.
March 2023 in “Revista Chilena de Urología” This review discusses post-finasteride syndrome, highlighting occasional adverse sexual and systemic effects in men and women, but reports no new research findings while emphasizing the need for better education about the drug's risks.
25 citations
,
January 2000 in “Hormone Research in Paediatrics” This article reviews androgen insensitivity syndrome and highlights the factors contributing to phenotypic diversity in 46,XY patients with AR gene mutations, reporting no new clinical results.
This study found that finasteride significantly reduced prostate weight and DHT levels in male mastomys, but not in females, suggesting unique androgen metabolism in female prostates.
September 2008 in “Fertility and Sterility” This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.
2 citations
,
January 2017 in “Iraqi journal of medical sciences” This study found that serum zinc levels were significantly decreased in obese women with polycystic ovary syndrome compared to their non-obese counterparts.
36 citations
,
October 2016 in “Bone” This case report describes a male patient with aromatase deficiency, revealing that a c.628G>A mutation can lead to varied clinical features, such as low bone mass and normal metabolic profiles.
104 citations
,
October 1999 in “The Journal of Urology” This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.
2 citations
,
May 2006 in “Women's Health Medicine” This article provides an overview of ovulation disorders, discussing ovarian, hypothalamic, and endocrine defects but reports no new clinical findings.
16 citations
,
June 2022 in “Transgender Health” This review suggests that oocyte retrieval may be viable for transgender men on testosterone therapy, with potentially manageable effects on fertility preservation without requiring extensive hormone suspension.
September 2021 in “Fertility and Sterility” This study found that older men in North America had longer infertility durations and were more likely to have partners who underwent IVF, with age impacting referral patterns and substance use behaviors.