In Vivo and In Vitro Exposure to Free Fatty Acids Induce Increased Androgen Production in Animal Models: A Potential Pathogenic Factor of Polycystic Ovary Syndrome

September 2008 in “ Fertility and Sterility ”

Catherine Baptiste, Xiuli Ci, Lucie Chouinard, N. Gallot-Payet, André C. Carpentier, Jean-Patrice Baillargeon

androgen free testosterone androstenedione dihydrotestosterone 3a-diol G dehydroepiandrosterone sulfate hyperandrogenemia polycystic ovary syndrome PCOS free fatty acids FFAs insulin resistance hyperandrogenism acne hirsutism testosterone DHT DHEA-S androgens fatty acids

Studysummary This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.

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