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research Serum 3α-androstanediol-glucuronide is decreased in nonhirsute women with acne vulgaris

10 citations , December 1996 in “Fertility and Sterility”

This study found that in women with acne vulgaris, lower serum levels of 3α-androstanediol-glucuronide suggest reduced 5α-reductase activity compared to controls, indicating that 5α-reductase inhibitors may not be effective for acne treatment.

research Female Androgenic Alopecia

14 citations , September 1986 in “Archives of Dermatology”

This study found that women with female pattern baldness had a marked increase in the 3α,17β-androstanediol glucuronide/sex hormone binding globulin ratio and low serum sex hormone binding globulin.

In Vivo and In Vitro Exposure to Free Fatty Acids Induce Increased Androgen Production in Animal Models: A Potential Pathogenic Factor of Polycystic Ovary Syndrome

research In vivo and in vitro exposure to free fatty acids induce increased androgen production in animal models: a potential pathogenic factor of the polycystic ovary syndrome

September 2008 in “Fertility and Sterility”

This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.

research 5α-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia

57 citations , November 2006 in “International Journal of Cancer”

This study found that the SRD5A2 A49T A variant is associated with an increased risk of prostate cancer, lower circulating 3α‐diolG levels, and a decreased risk of baldness.

research Finasteride in the treatment of hirsutism: new therapeutic perspectives

50 citations , July 1996 in “Fertility and Sterility”

This study found that finasteride significantly reduced hirsutism scores in women with idiopathic hirsutism and PCOS, despite no changes in serum androgen levels.

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Community Join

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community A lot of blood tests that I have done until now (Mainly Hormones).

4 upvotes 5 years ago

The user shared their experience with hair loss treatments, including oral and topical Finasteride and Minoxidil, and detailed various blood test results to track hormonal changes. They noted that while DHT levels initially decreased with topical Finasteride, they later increased, but they observed positive results in hair growth.

community Bloodwork: what to test for?

6 upvotes 6 years ago

The user has been taking oral Finasteride and topical Essengen 6 Plus for hair loss and is experiencing increased depression. They plan to get bloodwork to check hormone levels and are seeking advice on which tests to include.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

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Learn

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learn Propanediol

learn 3 aminopropane Sulfernic acid

learn PEG-120 Methyl Glucose Dioleate

learn 1,2-Hexanediol

learn Ethoxydiglycol

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