Editorial Comment

    December 2005 in “ The Journal of Urology ”
    Timothy J Wilt
    TLDR Combination therapy for BPH is more effective in certain men but may not be cost-effective due to minimal impact and potential side effects.
    The MTOPS trial investigated the long-term effects of doxazosin, finasteride, and their combination on BPH progression in men with moderate to severe LUTS. It found that combination therapy was more effective in men with higher PSA levels and larger prostate volumes, with a number needed to treat of 4.9 and 4.7 for specific subgroups compared to 8.4 for the entire cohort. Further analysis suggested benefits for men with prostate volumes of 25 to 40 ml, but the results were considered exploratory due to potential statistical chance from multiple subgroup analyses. The study highlighted a 50% relative decrease in progression, but the absolute decrease was minimal, raising questions about the cost-effectiveness of combination therapy given its low impact on clinical progression rates and potential adverse effects.
    Discuss this study in the Community →

    Related Community Posts Join

    2 / 2 results

      community Huberman tweet about finasteride

      in Finasteride/Dutasteride  278 upvotes 2 years ago
      The conversation is about the side effects of finasteride, including Post Finasteride Syndrome, with varied personal experiences and differing views on the credibility of information sources. Some participants also discuss using minoxidil as a hair loss treatment.

      community Warning: Minoxidil usage around pets

      in Minoxidil  454 upvotes 11 months ago
      Minoxidil is highly toxic to pets, especially cats and dogs, even in small amounts. Many users have switched to oral minoxidil to prevent accidental exposure to their pets.

    Related Research

    1 / 1 results