39 citations
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May 2011 in “Movement Disorders” Finasteride may help reduce symptoms in male Tourette syndrome patients.
October 2013 in “The professional medical journal” This study found a significant association between acne severity and serum LH/FSH ratio in women with polycystic ovarian syndrome, but not with serum testosterone levels.
1 citations
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April 2004 in “The Journal of Urology” This article discusses a novel approach to treating recurrent priapism in sickle cell anemia using Finasteride, but provides no new clinical findings.
25 citations
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November 2005 in “PubMed” This study found that finasteride altered androgen receptor expression in the rat epididymis without affecting the morphology of epididymal epithelium, suggesting a change in hormonal status.
100 citations
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April 2007 in “Neuroscience” This study found that treatment with finasteride in fetal sheep reduced the protective neurosteroid allopregnanolone, leading to increased cell death in the hippocampus following induced fetal asphyxia.
September 2004 in “Evidencia actualizacion en la práctica ambulatoria” This study found that the combination of finasteride and doxazosina was more effective in reducing the long-term progression of benign prostatic hyperplasia compared to monotherapy.
1 citations
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August 2023 in “Andrology” In this animal study, finasteride treatment altered testosterone metabolism in rat corpus cavernosum, linked to mechanisms of erectile dysfunction, but these changes were reversed after stopping the drug, suggesting post-treatment sexual side effects may relate more to central control dysfunction than peripheral issues.
6 citations
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February 2020 in “Journal of Natural Products” In this chemical investigation, cyclospongiaquinone 1 from the sponge Verongula cf. rigida showed strong steroid 5α-reductase inhibitory activity, comparable to that of finasteride.
April 2012 in “The Journal of Urology” In this study, men using Propecia for alopecia showed normal erectile hemodynamics despite erectile dysfunction after stopping 5-alpha reductase inhibitors, while some BPH patients exhibited abnormal results potentially linked to vascular risk factors.
May 2025 in “Veterinary Medicine and Science” In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.
January 2016 in “AACE Clinical Case Reports” In this case report, an embryonal cell carcinoma of the testicle was associated with polycythemia and markedly elevated hormone levels without secondary sexual characteristics, which were restored after treatment.
May 2003 in “Reactions Weekly” 66 citations
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March 1998 in “Mayo Clinic Proceedings” This case report describes a 70-year-old woman whose obstructive sleep apnea resolved after the removal of a testosterone-producing ovarian tumor, supporting the theory that testosterone influences OSA in women.
12 citations
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January 2016 in “Endocrinology, diabetes & metabolism case reports” This report describes a 19-year-old male with 49,XXXXY syndrome receiving testosterone replacement therapy, which led to improvements in reproductive development, metabolism, and social interaction after a year of treatment.
1 citations
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January 2018 in “PubMed” This study in Tehran found that, after adjusting for confounders, women with PCOS had no different risk of non-pregnancy after assisted reproductive treatment compared to women without PCOS.
October 2022 in “Journal of Pediatric and Adolescent Gynecology” This case study observed that unilateral oophorectomy may improve severe hyperandrogenism in adolescents with PCOS, even when imaging and SVS do not indicate neoplasm.
13 citations
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August 2013 in “Journal of pharmaceutical sciences” This study found that a transdermal delivery system using 3% azone and P407 gel may enhance the skin permeation of doxazosin and finasteride for treating benign prostatic hyperplasia.
5 citations
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September 2024 in “Stem Cell Research & Therapy” This study found that stem cell transplantation effectively reduced acute inflammation-induced testicular damage, suggesting potential for cell-based therapies in addressing male infertility.
41 citations
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June 1999 in “The Prostate” In this study, finasteride alone or combined with terazosin significantly reduced PSA levels in men with BPH, while terazosin alone did not affect PSA levels.
4 citations
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August 2010 in “Acta Biologica Hungarica” This study found that novel compounds moderately inhibited 5α-reductase type 1 activity compared to finasteride, offering valuable data on structure-activity relationships.
March 2023 in “Oxford University Press eBooks” The document's conclusion cannot be determined from the provided text.
3 citations
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July 2014 in “QJM” This case report discusses a 35-year-old man with progressive alopecia areata who did not respond to minoxidil treatment but offers no new clinical trial results.
January 2017 in “Cogent Medicine” In this study, extracts of Zataria multiflora Boiss. and Matricaria chamomilla, combined with minoxidil, significantly improved hair growth in androgenetic alopecia patients by potentially inhibiting 5α-reductase activity.
2 citations
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January 2016 in “Andrology” This case report study presents two instances of post-finasteride syndrome, highlighting the persistence of sexual adverse effects despite discontinuation of the drug, and underscores the need for increased awareness and understanding of this condition.
9 citations
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September 1996 in “PubMed” In this study, finasteride treatment for male pattern baldness improved hair loss and reduced prostate size, while increasing testosterone levels and altering steroid hormone ratios without affecting gonadotropin levels.
This study suggests that the negative impact of high-dose Finasteride on male reproductive function may be mitigated by concurrent administration with TU.
April 2015 in “The FASEB Journal” In this study, perinatal androgen deprivation in male rats led to elevated estrogen levels and a lack of sexual motivation towards gonadally-intact female rats.
January 2019 in “Indian Journal of Dermatology, Venereology and Leprology” 21 citations
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December 2015 in “Development Growth & Differentiation” This study introduces genital sex differentiation parameters (GSDP) to analyze sexual differences in external genitalia and perineum development in mice, revealing varied sensitivity to androgen inhibition in genital structures.
16 citations
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January 2017 in “Asian journal of andrology/Asian Journal of Andrology” This study found that older age at puberty may be associated with lower semen quality and altered reproductive hormone levels in young men, though only some results were statistically significant.