Testosterone Replacement in 49,XXXXY Syndrome: Andrological, Metabolic, and Neurological Aspects

    January 2016 in “ Endocrinology, diabetes & metabolism case reports ”
    Rossella Mazzilli, Michele Delfino, Jlenia Elia, Francesco Benedetti, Laura Alesi, Luciana Chessa, Fernando Mazzilli
    Image of study
    TLDR Testosterone therapy improved physical and social health in a male with 49,XXXXY syndrome.
    A 19-year-old male with 49,XXXXY syndrome, a rare genetic condition, exhibited congenital malformations, mental retardation, and delayed puberty. Initial treatments were limited to psychological support. Upon further examination, he was diagnosed with hypergonadotropic hypogonadism, insulin resistance, and vitamin D deficiency. After 12 months of testosterone replacement therapy, improvements were observed in testosterone levels, pubic hair growth, testicular volume, penis size, weight, insulin resistance, and vitamin D levels. Additionally, the patient showed better social interaction. The study highlighted the importance of early diagnosis and treatment for better outcomes in similar cases.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community For those on TRT and suffer from a more aggressive type of (AGA) hairloss, what are your hair safe protocols?

      in Chat  6 upvotes 1 year ago
      People on testosterone replacement therapy (TRT) with aggressive androgenetic alopecia (AGA) discuss using Dutasteride or Finasteride, sometimes combined with topical treatments like RU58841 or CB-03-01 (Breezula), to prevent hair loss. Concerns about side effects and costs of certain treatments are mentioned, with one individual sharing their experience of slowed hair loss using Finasteride alone.

      community TRT. Pyrilutamide. Ru58841. Help

      in Treatment  3 upvotes 8 months ago
      A 30-year-old man experienced significant hair loss after starting testosterone replacement therapy (TRT), which did not improve with daily finasteride and minoxidil. He is considering restarting TRT and is seeking advice on using pyrilutamide or RU58841 to prevent further hair loss.

      community my Body hair has stopped working

      in Finasteride/Dutasteride  44 upvotes 10 months ago
      A user on dutasteride for hair loss noticed hair regrowth on their head but a significant reduction in body hair growth. They plan to switch to finasteride and dutasteride and are considering testosterone replacement therapy but are concerned about its effects on hair growth.

      community From June 22 to August 23 slowww progress

      in Progress Pictures  13 upvotes 1 year ago
      The conversation is about a person's slow progress in treating hair loss using finasteride, microneedling, testosterone replacement therapy, dutasteride, RU58841, and minoxidil. They experienced a significant hair shed after adding dutasteride.

      community Low testosterone and dht. What should I do?

      in Finasteride/Dutasteride  6 upvotes 9 months ago
      The user has low testosterone and DHT levels and is considering taking finasteride for Norwood 2 hair loss with diffuse thinning. They are seeking advice on whether low DHT indicates high sensitivity to DHT in the scalp and opinions on their lab values.

    Similar Research

    5 / 1000+ results