The Effects of Perinatal Androgen Deprivation on Sexual Motivation in Male Rats

April 2015 in “ The FASEB Journal ”

Talha Khan, Alicia Yn, Dane Fickes, Pakou Vang, KumHwa Jeong, Binita Shah, Faeeq Yousaf, George T. Taylor, C. Gopalan

androgen deprivation flutamide androgen receptors estrogen gonadally-intact ovariectomized FLU

TLDR Blocking androgens at birth reduces sexual motivation in male rats.

The study investigated the effects of perinatal androgen deprivation on sexual motivation in male rats by using flutamide (FLU) to block androgen receptors during the perinatal period. The study involved 37 male rats divided into two groups, with one group receiving FLU and the other serving as a control. Results showed that rats treated with FLU had elevated serum estrogen levels and exhibited no preference between gonadally-intact and ovariectomized (OVX) female rats, indicating a lack of sexual motivation. In contrast, control rats showed a preference for gonadally-intact females. This suggested that perinatal androgen deprivation led to increased estrogen levels and diminished sexual motivation in male rats.

View this study on faseb.onlinelibrary.wiley.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 2 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community I Get Side-Effects from Anti-Androgens

in Finasteride/Dutasteride 7 upvotes 5 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 451 upvotes 1 year ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

community Can finasteride affect on your muscle and other things?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation discusses using finasteride topically for hair loss and concerns about potential side effects like feminization and impact on muscle growth. One person shared their experience with finasteride, indicating it increased testosterone and did not prevent them from gaining muscle or strength.

community For those on TRT and suffer from a more aggressive type of (AGA) hairloss, what are your hair safe protocols?

in Chat 6 upvotes 2 years ago

People on testosterone replacement therapy (TRT) with aggressive androgenetic alopecia (AGA) discuss using Dutasteride or Finasteride, sometimes combined with topical treatments like RU58841 or CB-03-01 (Breezula), to prevent hair loss. Concerns about side effects and costs of certain treatments are mentioned, with one individual sharing their experience of slowed hair loss using Finasteride alone.

community Is there a consensus on RU these days? Pyril turned out to be a bust right?

in Research/Science 17 upvotes 1 year ago

The conversation discusses the effectiveness and safety of hair loss treatments, specifically RU58841 and Pyrilutimide (Pyril), with users sharing that Pyril was no more effective than a placebo and expressing concerns about the safety of RU58841 based on personal experiences and the lack of pharmaceutical interest.

Similar Research

5 / 1000+ results

research The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats

14 citations , March 2018 in “Translational Stroke Research”

Finasteride helps protect brain in old male rats.

research Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage: An Experimental Animal Study

10 citations , May 2019 in “International Journal of Environmental Research and Public Health”

Finasteride may cause kidney damage.

Advances in Mitochondria-Centered Mechanism Behind the Roles of Androgens and Androgen Receptor in the Regulation of Glucose and Lipid Metabolism

research Advances in Mitochondria-Centered Mechanism Behind the Roles of Androgens and Androgen Receptor in the Regulation of Glucose and Lipid Metabolism

October 2023 in “Frontiers in endocrinology”

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

research Androgens and Cardiovascular Disease

658 citations , June 2003 in “Endocrine reviews”

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

research Redefining Hormone Resistance in Prostate Cancer

38 citations , December 2009 in “Therapeutic Advances in Medical Oncology”

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.