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research A placebo-controlled, double-blind crossover study of fluoxetine in trichotillomania

180 citations , November 1991 in “American Journal of Psychiatry”

This study found that fluoxetine did not demonstrate short-term efficacy in treating trichotillomania in a placebo-controlled, double-blind crossover setting.

research Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial

165 citations , February 1994 in “Fertility and Sterility”

This study found that flutamide was more effective than spironolactone in reducing symptoms of hirsutism and related conditions in premenopausal women, with fewer discontinuations due to side effects.

research Effects of Flutamide and Finasteride on Rat Testicular Descent

143 citations , August 1991 in “Endocrinology”

This study found that blocking androgen receptors inhibits testicular descent in rats more effectively during the early stages of gubernacular outgrowth than inhibiting 5a-reductase.

research Treatment of hirsutism with the pure antiandrogen flutamide

130 citations , September 1990 in “Journal of the American Academy of Dermatology”

This study found that combining flutamide with an oral contraceptive significantly reduced hirsutism, acne, and seborrhea in patients after seven months, without significant side effects.

research Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients

116 citations , May 1992 in “The American Journal of Medicine”

This study found that flutamide-induced liver toxicity in prostate cancer patients was very rare, occurring in only 0.18% of cases with clinical manifestations, and symptoms resolved after discontinuing the drug.

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Community Join

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community Fluridil (Eucapil) seems like a great option?

4 upvotes 9 months ago

The user stopped using finasteride due to side effects and is considering Fluridil (Eucapil) as an alternative for hair loss treatment. They are exploring other options like RU58841 and are interested in the experiences of others with Fluridil, noting its good safety profile despite the cost.

community Fluridil degrades the androgen receptor.

in Research/Science 12 upvotes 1 year ago

Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.

community What can I mix Eucapil (fluridil) with?

1 upvotes 1 year ago

Fluridil should not be mixed with minoxidil due to water content. Mixing with stemoxydine or alfatradiol is being considered for easier application.

community Does your hair also look depressingly awful under fluorescent lights?

in Chat 39 upvotes 1 year ago

Fluorescent lighting makes hair look thinner, causing concern about appearance. Some users consider treatments like DUT, while others share experiences of hair looking better in different lighting or conditions.

community Fluridil/Eucapil UAE customs regulation

in Chat 1 year ago

A user in the UAE is facing customs issues with ordering Fluridil (Eucapil) and is considering ordering smaller quantities or switching to Pyrilutamide. They are also using finasteride daily to maintain hair and are unsure of Fluridil's effectiveness.

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Learn

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learn Fluridil

a topical anti-androgen with less systemic involvement

Is Fluridil only for men with androgenetic alopecia, or can women use it too? The only published clinical study of fluridil enrolled 43 men, so its use in women is untested rather than established; women considering it should talk to a doctor, and it is not advised in pregnancy or breastfeeding because no reproductive-safety data exists.
Can daily Fluridil application stop hair follicle miniaturization? The single published fluridil trial (43 men, 9 months, double-blind and placebo-controlled) reported more hairs in the growth phase, but it never measured follicle diameter and has not been replicated — so whether daily use stops miniaturization is unproven, and community users describe stabilization rather than regrowth.
How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.
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What does Fluridil do on the scalp, and how does it block the DHT hormone? Fluridil blocks DHT by binding to androgen receptors in hair follicles, preventing hair loss.

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