Incidence of Liver Toxicity Associated with the Use of Flutamide in Prostate Cancer Patients

    May 1992 in “ The American Journal of Medicine ”
    José‐Luis Gomez, André Dupont, Lionel Cusan, M. Tremblay, Raul Suburu, Martin Lemay, Fernand Labrie
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    TLDR Flutamide rarely causes liver toxicity in prostate cancer patients.
    In a study of 1,091 prostate cancer patients treated with flutamide and a LHRH agonist, only four patients (0.36%) experienced significant liver toxicity, with two (0.18%) developing clinical liver disease. The toxicity resolved upon discontinuation of flutamide. The majority of patients had no or only mild and transient liver enzyme elevations. The study concluded that flutamide-induced liver toxicity is rare and recommended monitoring liver function at the start of treatment and after 2 and 4 weeks to quickly identify and manage any potential liver injury.
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