TLDR Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.
The document discussed the use of Triple Hormonal Blockade (ADT3) in managing prostate cancer, which involved a combination of a GnRH agonist or antagonist, an antiandrogen, and a 5Alpha Reductase inhibitor to effectively reduce testosterone and dihydrotestosterone (DHT) levels, thereby inhibiting cancer cell growth. It highlighted the importance of these medications in various treatment stages and emphasized the need for physicians to conduct necessary tests to rule out cardiac risks, especially in patients with pre-existing cardiovascular conditions, diabetes, or those over 70. The document also referenced a report suggesting that using the GnRH antagonist degarelix could potentially reduce cardiac events in patients with cardiovascular disease compared to GnRH agonists.
14 citations
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September 2015 in “Expert Opinion on Therapeutic Targets” The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
22 citations
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November 2018 in “Breast Cancer Research and Treatment” The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.
1 citations
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August 2022 in “Veterinary medicine and science” The main prostate diseases in dogs are benign growth, infections, and cancer, with various treatments ranging from drugs to surgery, but cancer treatments have limited success.
32 citations
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January 2018 in “American Journal of Clinical Dermatology” Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.
249 citations
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November 2003 in “Clinical endocrinology” Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
