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GlossaryGonadotropin-Releasing Hormone Antagonists (GnRH antagonists)

medications that block hormone signals to reduce sex hormone production

Gonadotropin-Releasing Hormone Antagonists (GnRH antagonists) are medications that block the action of GnRH, a hormone responsible for stimulating the release of other hormones like LH and FSH from the pituitary gland. By inhibiting this pathway, GnRH antagonists can reduce the production of sex hormones such as testosterone and estrogen, making them useful in treatments for conditions like prostate cancer, endometriosis, and certain fertility issues.

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research Treatment of Androgen Excess in Females: Yesterday, Today, and Tomorrow

9 citations, January 1997 in “Gynecological Endocrinology”

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

$Ovarian Stromal Hyperthecosis and Hyperandrogenemia Refractory to Hormonal Suppression$

research Ovarian Stromal Hyperthecosis and Hyperandrogenemia Refractory to Hormonal Suppression

2 citations, October 2015 in “Obstetrics and gynaecology cases - reviews”

Removing both ovaries may better treat increased male hormone levels and related symptoms in postmenopausal women when hormone therapy doesn't work.

research Triple Hormonal Blockade (ADT3): A Patient’s Perspective

January 2019 in “Oncogen”

Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.

research Slow Progress in Prostate Cancer

February 2007 in “BJUI”

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

research Pharmacological Control of Reproduction in Dogs and Cats

January 2019

Different drugs are used to manage breeding, prevent or end pregnancy, and treat reproductive issues in dogs and cats.

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community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.

in Transgender 128 upvotes 1 year ago

A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.

community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 113 upvotes 1 year ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 5 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.