Skin Epidermis and Adnexa Regrowth Induced by Treatment With Artificial Dermal Template After Full-Thickness Skin Wound

The document describes a study that found artificial dermal template (ADT) treatment can induce the regrowth of full-thickness skin, including the epidermis and adnexa such as hair follicles, in rodent models. The study observed that wound healing occurred through regeneration, with the presence of highly proliferative cells and immature hair follicles in the newly formed skin. Lgr5-positive hair follicle stem cells and Lgr6-positive cells were implicated in the regrowth process, and the WNT signaling pathway was found to be highly expressed, suggesting its role in skin regeneration. The study concludes that ADT treatment alone can stimulate full skin regrowth, including hair follicles, and holds potential for clinical applications in skin repair. However, the number of subjects used in the study was not specified in the summary, and further research, particularly in pig models, is recommended due to differences between rodent and human skin. The research was supported by the National Natural Science Foundation of China.