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GlossaryGonadotropin-Releasing Hormone Agonists (LHRH agonists)

medications that initially boost, then suppress, sex hormone production

Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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research Characteristics of Flutamide Action on Prostatic and Testicular Functions in the Rat

30 citations, June 1988 in “Journal of Steroid Biochemistry”

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

research Incidence of Liver Toxicity Associated with the Use of Flutamide in Prostate Cancer Patients

116 citations, May 1992 in “The American Journal of Medicine”

Flutamide rarely causes liver toxicity in prostate cancer patients.

research New Methods of Endocrine Management of Prostatic Cancer

67 citations, January 1987 in “The Journal of urology/The journal of urology”

New hormonal therapies can help treat advanced prostate cancer but may cause testicular issues.

research Therapeutic Control of Androgen Action

7 citations, January 1994 in “Annual Reports in Medicinal Chemistry”

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

research Onychomatricoma with Classic Features: Case Report and Review of the Literature

February 2013 in “Journal of The American Academy of Dermatology”

Hair loss is a common side effect of hormone treatments for cancer.

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in Research/Science 17 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.