3α-Androstanediol, But Not Testosterone, Attenuates Age-Related Decrements in Cognitive, Anxiety, and Depressive Behavior of Male Rats

January 2010 in “ Frontiers in Aging Neuroscience ”

Frye

3α-androstanediol testosterone androgens hippocampal

TLDR 3α-androstanediol helps reduce age-related cognitive and mood declines in male rats, unlike testosterone.

The study found that 3α-androstanediol, but not testosterone, effectively mitigated age-related declines in cognitive, anxiety, and depressive behaviors in male rats. It involved 248 male Fisher-344 rats across three age groups (4, 13, and 24 months) and used various behavioral tests to assess the effects. The results suggested that the beneficial effects of testosterone might be due to its metabolism into 3α-androstanediol, particularly in the hippocampus. The study highlighted the potential role of 3α-androstanediol in addressing age-related behavioral deficits, suggesting its importance in neuroprotection and mood regulation.

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