Disorders in Male Sexual Differentiation Due to 5α-Reductase-2 Deficiency

January 2018 in “ Elsevier eBooks ”

Yuan‐Shan Zhu, Julianne Imperato‐McGinley

5α-reductase-2 deficiency testosterone dihydrotestosterone DHT testosterone/DHT ratio virilization male pattern baldness prostate facial hair body hair sperm production 5-alpha-reductase-2 deficiency

Studysummary This review discusses the role of DHT in male sexual differentiation and fertility in individuals with 5α-reductase-2 deficiency, reporting no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents

93 citations , September 2014 in “Diabetes”

This study found that male 5αR1 knockout mice and obese Zucker rats treated with finasteride showed increased insulin resistance and hepatic steatosis, potentially implicating 5α-reductase activity in metabolic liver disease development.

research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

260 citations , July 2010 in “Cell”

This study identifies mutations in the SRD5A3 gene as a cause of a new type of congenital disorder of glycosylation, impacting mental, ophthalmologic, and cerebellar functions.

research An Overview on 5α-Reductase Inhibitors

219 citations , October 2009 in “Steroids”

5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.

research Natural Potent Androgens: Lessons from Human Genetic Models

60 citations , April 1998 in “Baillière s Clinical Endocrinology and Metabolism”

This article reviews the genetic mutations causing male pseudohermaphroditism from 17 beta-HSD-3 and 5 alpha-RD-2 deficiencies and reports no new clinical findings.

research 5 Alpha-Reductase-2 Gene Mutations in the Dominican Republic

53 citations , May 1996 in “The Journal of Clinical Endocrinology & Metabolism”

This study identified multiple mutations in the 5 alpha-reductase-2 gene among male pseudohermaphrodites in the Dominican Republic, suggesting they do not share a common ancestry.

research Structure of Human Type II 5 Alpha-Reductase Gene

124 citations , September 1992 in “Endocrinology”

This article discusses the structure of the human type II 5 alpha-reductase gene and reports no new experimental results.

research Effects of Flutamide and Finasteride on Rat Testicular Descent

143 citations , August 1991 in “Endocrinology”

This study found that blocking androgen receptors inhibits testicular descent in rats more effectively during the early stages of gubernacular outgrowth than inhibiting 5a-reductase.