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research Evaluation of dihydrotestosterone levels and total testosterone to dihydrotestosterone ratio with clinical symptoms and metabolic parameters in patients with polycystic ovary syndrome

November 2025 in “BMC Endocrine Disorders”

This study found that in PCOS patients, a lower TT/DHT ratio is associated with regular menstruation, while higher ratios are linked to insulin resistance, suggesting its potential as a biomarker for metabolic severity in these patients.

research Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients

9 citations , January 2017 in “Ginekologia Polska”

This study found that the total testosterone/dihydrotestosterone ratio correlates with a negative metabolic profile in both women with PCOS and healthy women.

research The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females

1 citations , October 2025 in “EBioMedicine”

Women have a higher DHT/testosterone ratio than men, possibly due to gut bacteria activity.

C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

research C₁₉and C₂₁5β/5αMetabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency*

55 citations , March 1990 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that finasteride decreased plasma dihydrotestosterone levels and altered steroid metabolism, similar to the profile of male pseudohermaphrodites with inherited 5a-reductase deficiency.

research Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss

27 citations , February 2017 in “Biomedicine & Pharmacotherapy”

This study found that white wax and its extract may promote hair growth in a mouse model of androgenetic alopecia by inhibiting 5α-reductase activity and increasing cell proliferation, with efficacy surpassing finasteride.

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Community Join

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community Does ZInc Increase or decrease DHT

4 upvotes 3 months ago

Zinc supplements may slightly increase DHT by affecting testosterone conversion, but are generally beneficial for health. A 15mg Zinc to 1mg Copper ratio is recommended.

community Turmeric Inhibits Conversion of Testosterone to DHT; Creatine Enhances It - Kyle Gillett

56 upvotes 4 years ago

Turmeric may slightly inhibit DHT, but it likely doesn't significantly impact hair loss. Creatine might increase DHT levels, but its effect on hair loss is debated and not conclusively proven.

community Testosterone and hair loss seeming irrelevance

82 upvotes 3 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community DHT Isn't (Directly) Important

101 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

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Learn

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learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn Ecklonia Cava

How does Ecklonia Cava help slow down hair loss in people with androgenetic alopecia? Ecklonia cava may slow hair loss by inhibiting the enzyme that converts testosterone to DHT.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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Experts

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