5 citations
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October 2010 in “General and Comparative Endocrinology” In this study, pregnant spotted hyenas treated with flutamide and finasteride had lower concentrations of several sex hormones, including testosterone and luteinizing hormone, compared to untreated controls.
26 citations
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March 2001 in “PubMed” This article reviews the effect of aging on male hormone levels and fertility, highlighting the need for more research on the benefits and risks of androgen supplementation in older men.
7 citations
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September 2022 in “Communications biology” This research found that Leydig cells significantly rely on synthesizing omega-6 HUFAs to support male steroid hormone production, highlighting a new role for these fatty acids in the male reproductive system.
This study found that prenatal exposure to finasteride in rats disrupted male reproductive development, causing physical alterations such as delayed preputial separation and increased nipple retention.
2 citations
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December 2001 in “PubMed” In this review, the authors found no evidence of harmful pregnancy outcomes from exposure to finasteride, and report that handling the medication poses negligible risk to a fetus.
September 2025 in “Toxicology” Long-term use of finasteride and minoxidil may harm male reproductive health in mice.
December 2025 in “Journal of Inflammation Research” This study found that BAMO acupuncture combined with Simiao pill can help restore normal prostate tissue structure in mice by reducing DHT production, promoting apoptosis, and decreasing inflammatory responses.
January 2022 in “Drug Delivery” This study investigated a finasteride and oregano oil-loaded nano-cubosome gel formulation, finding it enhanced drug release and skin permeation and demonstrated synergistic antibacterial effects, suggesting potential for treating alopecia areata.
1 citations
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January 2018 in “AUSTRALIAN JOURNAL OF BASIC AND APPLIED SCIENCES” In this study, the ethanol extract of Zapoteca portoricensis stem significantly reduced markers of testosterone-induced benign prostate hyperplasia in male albino rats without harming liver and kidney function.
December 2023 in “Magna Scientia Advanced Research and Reviews” This study proposes that combining trazodone and clomiphene citrate could potentially restore libido synaptic circuits and treat post-finasteride syndrome, which involves persistent sexual dysfunction after discontinuing finasteride treatment.
26 citations
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September 2005 in “Pharmacology Biochemistry and Behavior” This study found that inhibiting the 5alpha-reductase 2 pathway in male rats affects brain sexual differentiation and leads to reproductive changes, including increased pre-implantation loss despite unchanged copulatory potential.
1 citations
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August 2025 in “Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine” BMI should be considered in future research on dutasteride's effects on fertility.
7 citations
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January 2017 in “Indian Journal of Dermatology, Venereology and Leprology”
16 citations
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April 2007 in “Journal of Obstetrics and Gynaecology Research” In this study, serum PSA levels were higher in women with PCOS, suggesting it may serve as a marker for hyperandrogenism in this condition.
3 citations
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October 2015 in “PubMed” This study found an increased risk of intraoperative iris billowing in rabbits treated with finasteride, similar to those treated with tamsulosin, suggesting further research in humans is needed.
May 2007 in “The Journal of Urology” Finasteride lowers PSA levels in men, certain factors increase testicular cancer risk, and current guidelines for penile cancer may lead to unnecessary surgeries.
2 citations
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November 2017 in “Gynecological Endocrinology” This study found that serum myo-inositol oxygenase levels do not differ between women with polycystic ovary syndrome and healthy controls, suggesting that MI deficiency in PCOS is not due to MIOX levels.
January 2020 in “Skinmed” Zinc levels are not significantly different in people with hair loss conditions like Androgenetic Alopecia and Alopecia Areata.
February 2017 in “The Journal of Sexual Medicine” This study found that young men using finasteride for androgenic alopecia exhibited erectile tissue fibrosis and associated sexual dysfunction, including low libido and mood changes.
September 2018 in “Translational Andrology and Urology” This study found that finasteride was associated with increased erectile dysfunction in men with benign prostatic hyperplasia, but this association was not statistically significant in those with male androgenic alopecia.
September 2022 in “Journal of Contemporary medical practice” This study found that among women with polycystic ovarian disease, 72% experienced infertility, indicating a correlation between PCOD and difficulties in conceiving.
June 2018 in “The Journal of Sexual Medicine” This study found no significant difference in semen parameters or reproductive hormone levels between men taking low-dose finasteride for androgenic alopecia and those not on the medication.
November 2008 in “Central Plains Medical Journal” This study found that combining zinc with topical minoxidil significantly improved curative rates in treating androgenetic alopecia after 9 and 12 months compared to zinc alone.
118 citations
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May 2003 in “Toxicological Sciences” This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.
6 citations
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December 2022 in “International Journal of Molecular Sciences” This study revealed that deleting EZH2 in mesenchyme-derived cells of the female reproductive tract led to impaired uterine gland development and pregnancy loss in mice, highlighting EZH2's crucial role in fertility.
December 2016 in “The Journal of Sexual Medicine” This study found that young men using finasteride for androgenic alopecia experienced erectile dysfunction and signs of erectile tissue fibrosis, alongside symptoms like low libido and mood changes.
February 2004 in “European Urology Supplements”