1 citations
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May 2015 in “Journal of The American Academy of Dermatology” Finasteride for hair loss in young men may significantly increase the risk of sexual dysfunction.
124 citations
,
July 1997 in “Journal of Biological Chemistry” This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.
91 citations
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July 2004 in “Journal of Biological Chemistry” This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.
January 2012 in “Medical Journal of Babylon” June 2020 in “Mağallaẗ al-anbār li-l-ʻulūm al-bayṭariyyaẗ” This study found that finasteride reduced sperm count, motility, and levels of reproductive hormones, indicating negative effects on fertility in albino male rats.
1 citations
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August 2020 in “REMUS - Revista Estudiantil de Medicina de la Universidad de Sonora” This study found a positive association between erectile dysfunction and the functionality of the marital subsystem in patients with benign prostatic hyperplasia treated with tamsulosin and finasteride.
2 citations
,
November 2018 in “International journal of gynaecology and obstetrics” In this retrospective cohort study, no significant differences were observed in assisted reproductive outcomes among different PCOS phenotypes undergoing frozen-thawed embryo transfer.
This study found that finasteride reduces microvascular density and VEGF expression in the seminal vesicle tissue of rats.
August 2015 in “대한피부미용학회지” This study observed that zinc sulfate improved hair growth in a mouse model of alopecia, suggesting potential as a therapeutic agent, though less effective than minoxidil.
7 citations
,
March 2017 in “Medical Hypotheses” This study suggests that dysfunctions and altered expression of aquaporins may play a role in PCOS-related disorders, potentially impacting folliculogenesis and integrating with the insulin-dependent hypothesis of PCOS pathogenesis.
1 citations
,
January 2002 in “Yaoxue jinzhan” This study found that Epristeride and Finasteride reduced prostate development and testis weight in male rats, but only Finasteride appeared to impact reproductive function.
1 citations
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September 2025 in “Archivio Italiano di Urologia e Andrologia” In this study, the combination of Serenoa repens extract with Phenolmicin P3 and Bosexil suppositories significantly improved lower urinary tract symptoms and decreased PSA levels in patients with benign prostatic obstruction-related symptoms.
1 citations
,
July 2025 in “Journal of Chemical Biological and Physical Sciences” This study found that women with polycystic ovary syndrome have higher rates of infertility, shorter reproductive spans, and poorer fertility outcomes compared to healthy controls.
1 citations
,
September 2015 in “Human Andrology” Married Egyptian women with PCOS have lower sexual desire compared to those without PCOS.
5 citations
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May 2020 in “Diagnostics” This study involving male patients with androgenic alopecia found that a higher baseline zinc plasma level, specifically above 10 µmol/L, may predict the success of treatment with 5% topical minoxidil, correlating with increased hair density and diameter in the parietal area.
March 2025 in “Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine” This study found that long-term use of dutasteride in men taking it for androgenetic alopecia may lead to persistent decreases in semen volume and sperm motility, potentially impacting fertility, with significant impairment observed after 17.8 to 20.3 months of treatment.
47 citations
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April 2003 in “Journal of dermatological science” This study showed that Thujae occidentalis semen extract inhibited 5alpha-reductase type 2 in laboratory tests and reduced androgen-related hair loss in animal models, suggesting potential use for male pattern baldness.
March 2014 in “International Society of Hair Restoration Surgery” This abstract discusses the effects of finasteride on semen and hormone parameters in men with infertility but does not provide new research findings.
January 2023 in “Indian Dermatology Online Journal” This case report describes a novel association between uncombable hair syndrome and Zellweger syndrome due to a homozygous mutation in the PEX12 gene.
5 citations
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January 2018 in “Research Journal of Pharmacy and Technology” In this rat study, finasteride treatment significantly reduced body, testis, epididymis, and prostate weights and affected testicular histology, indicating potential negative impacts on testicular function.
6 citations
,
October 2018 in “Endocrinology” This study indicates that sheep prenatally androgenized with testosterone show wool fiber diameter changes that parallel the increased hair diameter in women with polycystic ovary syndrome.
February 2024 in “International journal of pharmaceutical sciences and nanotechnology” In this article, researchers explored the potential of lipidic nanocarriers to enhance the delivery and effectiveness of finasteride in a topical gel form for androgenic alopecia, aiming to improve treatment options and reduce systemic adverse effects.
11 citations
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September 2015 in “Theriogenology” Testosterone boosts fluid and electrolyte secretion in seminal vesicles, aiding sperm function.
January 2022 in “Voennaâ medicina” This case study describes a successful treatment of androgenetic alopecia in a 34-year-old man through a comprehensive program involving low-dose minoxidil, without finasteride, resulting in significant hair growth improvements.
3 citations
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January 2021 in “Andrology” This study found that low androgen levels in rat penile endothelial cells were associated with a decrease in eNOS-expressing extracellular vesicles and reduced nitric oxide production.
April 2025 in “The Egyptian Journal of Hospital Medicine” This study suggests that expanding the Egyptian premarital screening program to include dermatological conditions, sexually transmitted diseases, and andrological disorders could enhance marriage stability.
3 citations
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April 2003 in “BJUI” Doxazosin alone or combined with finasteride improves prostate symptoms better than finasteride alone, without extra benefits.
January 2025 in “Indian Journal of Animal Research” This study observed that herbal feed supplementation in Frieswal breeding bulls improved semen volume and motility, while significantly lowering dihydrotestosterone levels, suggesting a potential mechanism for enhancing semen quality.
1 citations
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January 2023 in “Journal of Obstetrics and Gynaecology” This study found that pregnant Egyptian women with PCOS and recurrent miscarriages showed elevated DHEA levels and shortened cervical length, which may negatively impact pregnancy outcomes.
May 2015 in “Journal of The American Academy of Dermatology” Young men taking finasteride for hair loss have a higher risk of sexual dysfunction.