Physiological and Histological Study of the Effect of Finasteride Drug (Prostacare) on the Fertility of Albino Male Rats

January 2018 in “ Research Journal of Pharmacy and Technology ”

Fahad Najd Obaid, Haider Salih Jaffat

finasteride Prostacare testis epididymis prostate gland seminiferous tubules Leydig cells necrosis

TLDR Finasteride significantly reduces fertility in male rats.

The study investigated the effects of finasteride (Prostacare) on the fertility of albino male rats. Forty-five male rats were divided into three groups: a control group and two groups receiving finasteride at 5 mg/kg and 10 mg/kg daily for eight weeks. Results indicated a significant decrease (p<0.05) in the weights of the body, testis, epididymis, and prostate gland in the finasteride-treated groups compared to the control. Histological examination revealed a significant reduction (p<0.05) in seminiferous tubules diameters and the number of Leydig cells, along with increased interstitial space between tubules. Additionally, necrosis was observed in the seminiferous tubules of the testis.

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