Physiological and Histological Study of the Effect of Finasteride Drug (Prostacare) on the Fertility of Albino Male Rats

January 2018 in “ Research Journal of Pharmacy and Technology ”

Fahad Najd Obaid, Haider Salih Jaffat

finasteride Prostacare testis epididymis prostate gland seminiferous tubules Leydig cells necrosis

TLDR Finasteride significantly reduces fertility in male rats.

The study investigated the effects of finasteride (Prostacare) on the fertility of albino male rats. Forty-five male rats were divided into three groups: a control group and two groups receiving finasteride at 5 mg/kg and 10 mg/kg daily for eight weeks. Results indicated a significant decrease (p<0.05) in the weights of the body, testis, epididymis, and prostate gland in the finasteride-treated groups compared to the control. Histological examination revealed a significant reduction (p<0.05) in seminiferous tubules diameters and the number of Leydig cells, along with increased interstitial space between tubules. Additionally, necrosis was observed in the seminiferous tubules of the testis.

View this study on indianjournals.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Getting Ed from 1mg of fin not sure what to do

in Finasteride 190 upvotes 1 month ago

The user experienced erectile dysfunction from 1mg finasteride and sought advice on whether to continue, reduce dosage, or switch treatments. Suggestions included switching to topical finasteride, adding minoxidil, or trying dutasteride.

community Topical finasteride in liposomal formulation

in Finasteride 5 upvotes 4 years ago

Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

community 10 Years on Fin + Min: My story & insight on sides.

in Finasteride 130 upvotes 4 years ago

User shares 10-year experience using Finasteride and Minoxidil for hair loss with positive results and no significant side effects. Others suggest consistency, microneedling, and considering hair transplants.

community Dutasteride Mega Guide – Better Than Finasteride?

in Finasteride 88 upvotes 4 years ago

The potential risks and benefits of using Dutasteride as a hair loss treatment, compared to using Finasteride or other treatments like RU58841 or Accutane. People discussed their personal experiences with these treatments and shared advice on how to proceed.

community Tried to get a finasteride prescription but doc says I'm too young and warned me of sides. I'm 22. Says I should only use minox.

in Finasteride 22 upvotes 4 years ago

A 22-year-old was advised by their doctor to use 5% minoxidil for hair loss instead of finasteride due to age and potential side effects. Other users suggested either persisting with the doctor or finding a new one, sharing mixed experiences with finasteride.

community There's been a lot of interest in Liposomal Finasteride ever since that one study came out that it was the most effective than all other topical finasteride solutions. Liposomal solutions are actually dirt cheap and easy to make. Comes out to only a couple bucks a month if you get the 15$ costco fin

in Finasteride 2 upvotes 4 years ago

The conversation is about using liposomal finasteride for hair loss treatment, highlighting its cost-effectiveness and ease of preparation. It suggests using lecithin and crushed finasteride pills to make the solution, which has shown to be significantly more effective than other topical formulations.