TLDR Ganoderma lucidum may help treat enlarged prostate in rats.
The document reports a study on the effects of Ganoderma lucidum (GL) extracts on testosterone-induced prostatic hyperplasia in rats. The study found that GL extracts, particularly the petroleum ether extract (GLP) and the ethanolic extract (GLE), were effective in reducing prostate weight and the prostate/body weight ratio, improving urine output, and decreasing prostate-specific antigen (PSA) levels. GLP was slightly more effective than GLE, with a 71.57% recovery in the prostate/body weight ratio at a dose of 50 mg/kg, compared to a 68.94% recovery for GLE at the same dose. Finasteride, a known treatment for hyperplasia, showed an 80.10% recovery. The study concluded that GL extracts have potential as a treatment for benign prostatic hyperplasia due to their 5α-reductase inhibitory activity and the observed improvements in prostatic histoarchitecture. The number of rats used in the study was not specified in the provided excerpt.
5 citations
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March 2006 in “Food Chemistry” The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.
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July 2005 in “Journal of Ethnopharmacology” Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.
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December 2001 in “Urology” Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.
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January 2000 in “European Urology” Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.
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May 2014 in “Expert Opinion on Therapeutic Targets” The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
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March 2006 in “Food Chemistry” The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.
August 2023 in “Malaysian Journal of Medicine and Health Sciences/Malaysian journal of medicine and health sciences” Pueraria mirifica extract may help treat benign prostatic hyperplasia.
