Effects of Androgen on Extracellular Vesicles from Endothelial Cells in Rat Penile Corpus Cavernosum

    January 2021 in “ Andrology ”
    Ling‐Tao Yan, Zhihui Yang, Haocheng Lin, Jun Jiang, Rui Jiang
    TLDR Low androgen levels reduce nitric oxide production in rat penile cells.
    The study explored the impact of dihydrotestosterone (DHT) on extracellular vesicles (EVs) from endothelial cells in the rat penile corpus cavernosum, involving five male Sprague Dawley rats. It found that higher DHT levels were associated with increased EV content and protein expression, such as CD9, CD63, TSG101, and eNOS, which are crucial for erectile function. Low DHT levels inhibited the release of eNOS-expressing EVs and reduced nitric oxide (NO) production, potentially contributing to erectile dysfunction (ED) by decreasing NO in penile tissue. The research suggested that EVs might influence erectile function by inhibiting apoptosis in endothelial and smooth muscle cells, and recommended further studies to explore EVs' potential in improving erectile function in ED patients with low androgen levels.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  43 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Serum based on plant extracts boosts hair growth in weeks.

      in Treatment  40 upvotes 2 months ago
      A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  414 upvotes 8 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community My Theory Of Androgenic Alopecia

      in Research/Science  17 upvotes 1 month ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

    Related Research

    1 / 1 results