Does Myo-Inositol Oxygenase, the Only Enzyme to Catalyze Myo-Inositol In Vivo, Play a Role in the Etiology of Polycystic Ovarian Syndrome?

    November 2017 in “ Gynecological Endocrinology ”
    Cuma Mertoglu, Murat Gunay, Vahdet Gul, Mehmet Kulhan, Mehmet Aktas, Taha Abdulkadir Coban
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    TLDR The enzyme myo-inositol oxygenase is not linked to the cause of polycystic ovarian syndrome.
    The study compared serum myo-inositol oxygenase (MIOX) levels in 60 newly diagnosed PCOS patients with 60 healthy controls and found no significant difference, indicating that MIOX does not contribute to the etiology of PCOS. Median MIOX levels were 19.4 in the control group and 16.4 in the PCOS group, with a p-value of 0.7428. The only noted difference between the groups was a higher lymphocyte count in the PCOS group. The study suggests that myo-inositol deficiency in PCOS is not due to altered MIOX levels and acknowledges the limitation of not measuring urinary MIOX and inositol levels, recommending further research into alternative myo-inositol clearance mechanisms.
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