Trazodone Associated With Clomiphene: A Proposal Treatment for Post-Finasteride Syndrome

The document proposes a treatment for post-finasteride syndrome, a condition where sexual dysfunction persists even after discontinuing the drug finasteride, which is used for androgenetic alopecia and benign prostatic hyperplasia. The proposed treatment involves the use of trazodone and clomiphene. Trazodone is a multifunctional drug that can cause severe priapism and in many cases causing penile necrosis or permanent loss of erectile function. Clomiphene citrate is a selective estrogen receptor modulator used for the treatment of hypogonadism in men, acting centrally to increase secretion of luteinizing hormone. The researchers suggest that these drugs can restore libido synaptic circuits, potentially offering a solution for post-finasteride syndrome.