Pharmacovigilance Analysis of Reports of Sexual Dysfunction Associated with Finasteride Use: Implications for the Post-Finasteride Syndrome

    April 2022 in “ The Journal of Sexual Medicine ”
    Duong Nguyen, P. Herzog, Eugene B. Cone, M. Labban, K. Zorn, Bilal Chughtai, Shehzad Basaria, Dean Elterman, Q-D. Trinh, Naeem Bhojani
    TLDR Finasteride is linked to sexual dysfunction, especially in younger users treating hair loss.
    This study analyzed 7,700 reports of sexual dysfunction associated with finasteride, a drug used for androgenetic alopecia and benign prostatic hyperplasia, using the WHO's VigiBase. The findings revealed a significant disproportionality signal for sexual dysfunction, particularly in patients under 45 and those using finasteride for alopecia, with a reporting odds ratio (ROR) of 64.9 for alopecia patients. Sensitivity analyses confirmed the significance of these signals, suggesting that while some reports may be influenced by indication and reporting biases, these factors alone do not fully explain the observed effects in younger alopecia patients.
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