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Primary cicatricial alopecia, a rare disorder causing permanent hair loss, is hard to diagnose and treat, with treatments like anti-inflammatory drugs and steroids offering varied results and no guaranteed cure. Psychological support for patients is important, and future research should aim to identify causes of the condition.

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Desmoglein 4 is controlled by specific proteins that affect hair growth.

New hair growth corticosterone levels are higher in diabetic mice, indicating long-term stress.

TGase 3 helps build hair structure by forming strong bonds between proteins.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Notch signaling disruptions can cause various skin diseases.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

sPLA2-IIE is crucial for normal hair follicle structure and skin health.

Phospholipase A2 enzymes play key roles in skin health and disease.

Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

Genetic discoveries are leading to new treatments for alopecia areata.

TGM3 is important for skin and hair structure and may help diagnose cancer.

English springer spaniels are more prone to severe sebaceous adenitis than standard poodles.

Trichoscopy can diagnose monilethrix, a genetic hair defect causing hair thinning and loss.

A gene variant increases the risk of a type of hair loss by affecting hair protein production.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

The AVET system effectively delivers genes to human keratinocytes and may help treat skin diseases.

Sox6 is important in heart and kidney health, affecting diseases like diabetes, heart disease, and high blood pressure.

Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.

EGFR helps control how hair grows and forms without needing p53 protein.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

Tofacitinib helps regrow hair in severe alopecia patients, but more research is needed.

The UD-PrOZA program successfully diagnosed 18% of adult patients with rare diseases, often using genetic testing.

B6.Cg-Tyr c−2J Hr hr /J mice have a stronger delayed sunburn reaction and are good for UV research.