Hair Corticosterone Measurement in Mouse Models of Type 1 and Type 2 Diabetes Mellitus

In this study, researchers measured corticosterone levels in hair to assess cumulative stress in rodent models of type 1 and type 2 diabetes mellitus. They found that corticosterone levels in new growth hair and serum were significantly elevated in diabetic mice compared to controls, while levels in old hair growth did not differ significantly. This indicated that sampling new hair growth was more sensitive for detecting changes due to hyperglycemia. The findings validated the use of hair corticosterone as a measure of long-term stress in diabetic rodents, suggesting potential for similar applications in humans.