Hair Corticosterone Measurement in Mouse Models of Type 1 and Type 2 Diabetes Mellitus

January 2017 in “ Physiology & Behavior ”

Rebecca L. Erickson, Caroline A. Browne, Irwin Lucki

corticosterone hair corticosterone diabetes mellitus type 1 diabetes type 2 diabetes hyperglycemia

TLDR New hair growth corticosterone levels are higher in diabetic mice, indicating long-term stress.

The study investigated hair corticosterone levels in mouse models of type 1 and type 2 diabetes mellitus to understand the relationship between chronic stress and diabetes. Researchers found that both types of diabetic mice exhibited significantly higher hair corticosterone levels compared to non-diabetic controls, indicating elevated chronic stress. New hair growth showed more significant differences than old hair growth, suggesting it is a more sensitive method for detecting stress due to hyperglycemia. The study concluded that hair corticosterone could serve as a biomarker for chronic stress in diabetic conditions, with potential applications in monitoring diabetic complications and treatment efficacy.

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