Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes

This document reviews the role of circadian rhythms in the development and management of type 2 diabetes mellitus (T2DM). It explains how disruptions in circadian rhythms, such as those caused by shift work, altered sleep-wake cycles, and mutations in clock genes, can contribute to the onset and progression of T2DM. The review cites a meta-analysis of 12 cohort studies involving 244,266 participants, which found a 1.14 relative risk of developing diabetes among shift workers. It also discusses the potential benefits of interventions that align with circadian rhythms, such as improving sleep quality, morning exercise, and time-restricted eating, in managing T2DM. The document calls for future research on the clinical impact of circadian disruption on diabetes complications and the development of therapeutic strategies that consider circadian physiology.