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    Glossary Atrophic Acne Scars

    indentations in the skin from insufficient collagen after severe acne

    Atrophic acne scars, also known as depressed or pitted acne scars, are indentations in the skin that occur when the skin does not produce enough collagen during the healing process after severe acne. These scars are characterized by their sunken appearance and can be classified into three main types: ice pick, boxcar, and rolling scars, each with distinct shapes and depths.

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    1. Combined autologous platelet-rich plasma with microneedling verses microneedling with distilled water in the treatment of atrophic acne scars: a concurrent split-face study Journal of Cosmetic Dermatology · 2016 · 106 citations
    2. The efficacy in treatment of facial atrophic acne scars in Asians with a fractional radiofrequency microneedle system 2013 · 51 citations
    3. Serial sections of atrophic acne scars help in the interpretation of microscopic findings and the selection of good therapeutic modalities Journal of the European Academy of Dermatology and Venereology · 2011 · 36 citations
    4. A Meta-analysis of the Evidence for Assisted Therapy with Platelet-Rich Plasma for Atrophic Acne Scars Aesthetic Plastic Surgery · 2019 · 16 citations
    5. Study to compare the efficacy of 50% glycolic acid with 65% trichloroacetic acid in the treatment of atrophic acne scar by CROSS technique Journal of Cutaneous and Aesthetic Surgery · 2024 · 1 citations
    6. Fluid Platelet-Rich Fibrin (PRF) Versus Platelet-Rich Plasma (PRP) in the Treatment of Atrophic Acne Scars: A Comparative Study Archives of Dermatological Research · 2022 · 1 citations
    7. Fractional microneedle radiofrequency for photoaging and atrophic acne scar: a split-face clinical observation of two devices Lasers in Medical Science · 2026
    8. Efficacy and safety of autologous cell-based therapies for atrophic acne scar treatment: an updated systematic review and meta-analysis with in-depth methodological and clinical insights Frontiers in Cell and Developmental Biology · 2026
    9. Human insulin via MMP® for treating atrophic acne scars: a pilot study Insulina humana via MMP® para cicatrizes atróficas de acne: estudo piloto. International Journal of Health Science · 2026
    10. Synergistic Effects of Fractional CO <sub>2</sub> Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling Dermatologic Therapy · 2025
    11. Role of platelet rich plasma therapy in the treatment of alopecia areata and atrophic acne scars IP Indian journal of clinical and experimental dermatology · 2024
    12. Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars Australasian journal of dermatology · 2024
    13. 604 Comparison of 1064-nm Nd:YAG picosecond lasers using fractional micro-lens array vs. ablative fractional 2940-nm Er:YAG lasers for the treatment of atrophic acne scar in Asians: A 20-week prospective, randomized, split-face, controlled trial Journal of Investigative Dermatology · 2023
    14. Combined treatment modalities in atrophic acne scars: a prospective study International journal of research in dermatology · 2019
    15. Use of Microneedling with Platelet Rich Plasma for Management of Atrophic Post-Acne Scars: Review Article The Egyptian Journal of Hospital Medicine · 2023 · 1 citations
    16. Updated Management of Atrophic Post Acne Scars: Review Article ˜The œEgyptian Journal of Hospital Medicine · 2021
    17. Potential genetic associations of acne scar phenotypes: IL1A in fibrotic scarring and CYB5R1 in atrophic scarring Biomedical Research and Therapy · 2026
    18. Combined Effect of Microneedling and Platelet-Rich Plasma for the Treatment of Acne Scars: A Meta-Analysis Frontiers in Medicine · 2022 · 7 citations
    19. Comment on “Platelet-rich plasma and its utility in the treatment of acne scars: A systematic review” Journal of The American Academy of Dermatology · 2019 · 4 citations
    20. A split face study to compare the efficacy of platelet rich plasma versus normal saline injections in acne scars and to assess the utility of ultrabiomicroscopic sonography in evaluation of treatment response Journal of Cutaneous and Aesthetic Surgery · 2022 · 2 citations
    21. Subcision with Blunt Cannula in Combination with Injection of PRP and Microneedling in Treatment of Acne Scar The Egyptian Journal of Hospital Medicine · 2023 · 1 citations
    22. Efficacy of Platelet Rich Plasma in Treatment of Acne Scars Benha Journal of Applied Sciences · 2021
    23. Acne Scar Management: Minoxidil as a Promising Approach or a Mirage? International journal of biomedicine · 2023
    24. Polynucleotides High Purification Technology: A Real-World Prospective Study in a Hospital Outpatient Setting Supports PN HPT as a Regenerative Medicine Option for Acne Scar Management Clinical Cosmetic and Investigational Dermatology · 2026
    25. Efecto del plasma rico en plaquetas en el tratamiento de las cicatrices por acné: revisión sistemática y metaanálisis Universidad Peruana de Ciencias Aplicadas (UPC) · 2020
    26. Study of Efficacy and Safety of Platelet Rich Plasma Therapy Combined Withmicroneedling on Acne Scars International Journal of Contemporary Medicine · 2020
    27. Microneedling: Where do we stand now? A systematic review of the literature Journal of Plastic Reconstructive and Aesthetic Surgery · 2017 · 92 citations
    28. Effectiveness of Radiofrequency Microneedling in the Treatment of Dermatological Conditions: A Systematic Review Aesthetic Plastic Surgery · 2026 · 1 citations
    29. Fractional resurfacing in the Asian patient: Current state of the art Lasers in Surgery and Medicine · 2016 · 33 citations
    30. Lasers, Microneedling, and Platelet-Rich Plasma for Skin Rejuvenation and Repair Facial Plastic Surgery Clinics of North America · 2018 · 18 citations