A Meta-Analysis of the Evidence for Assisted Therapy with Platelet-Rich Plasma for Atrophic Acne Scars

    September 2019 in “ Aesthetic Plastic Surgery ”
    Tyng Shiuan Hsieh, Wen Kuan Chiu, Ten Fang Yang, Hsian-Jenn Wang, Chiehfeng Chen
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    TLDR Platelet-rich plasma therapy helps improve atrophic acne scars.
    The meta-analysis reviewed seven studies with a total of 249 participants to evaluate the effectiveness of platelet-rich plasma (PRP) as an assisted therapy for atrophic acne scars. The studies involved treatments like fractional carbon laser therapy and microneedling in combination with PRP. Results showed a significantly higher improvement in the PRP group compared to the control group, with an odds ratio of 8.19 and a weighted mean difference in improvement score of 23.73, both with p-values less than 0.00001, despite substantial heterogeneity among the studies. Side effects such as erythema and edema were fewer in the PRP groups, but not to a statistically significant extent. The analysis concluded that PRP is a useful assisted therapy for atrophic acne scars, but further large-scale studies are needed to confirm these findings.
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