Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, alopecia areata patients treated with diphencyprone showed a significant increase in CD8 lymphocytes around hair bulbs, which may be associated with hair regrowth.

This study observed four consanguineous families with congenital atrichia with papular lesions and identified three novel mutations in the hairless gene, which may contribute to the disorder.

This study found that encapsulating ascorbyl palmitate in curcumin-grafted nanoparticles increased its stability compared to unencapsulated forms, with primary skin penetration occurring through hair follicles in pig skin.

This study found that nanoemulsions of different sizes vary in their ability to penetrate skin layers, with smaller sizes aiding transdermal delivery and potential applications in transcutaneous immunization.

This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.

This review discusses the unique advantages and challenges of microneedle arrays for vaccine and immunotherapy delivery but reports no new clinical results.

This study found that transfollicular delivery using surfactant-based nanoparticles significantly enhanced antigen stability and immune response compared to other delivery methods, especially when combined with an adjuvant.

This study developed PiSCES biosignatures that distinguished alopecia areata patients from controls, revealing enhanced basal TCR signaling and a potential disease-specific signaling network signature.

OX40-targeted therapies may help treat skin diseases by reducing inflammation and balancing immune responses.

This study found that oral tofacitinib was effective in promoting hair regrowth in patients with alopecia universalis, although further controlled studies are recommended to confirm its safety and efficacy.

This review explores recent advances in inflammation resolution and considers how macrophage reprogramming might help address severe COVID-19 outcomes, particularly those involving cytokine storms, but it reports no new experimental results.

This study investigated different centrifugation systems and found that low-speed protocols and certified centrifuges produced better-quality platelet-rich fibrin and recommended using FDA-approved glass tubes for safe and effective regenerative outcomes.

Researchers demonstrated that a new vaccine platform using antigen-loaded hydrogels enhanced humoral immune responses in mice, producing stronger antigen-specific antibody levels compared to the conventional adjuvant Alum, and offering promising protective capabilities against influenza virus.

This study found that primary stem cells from concentrated growth factor can differentiate into adipogenic, endothelial, and neuronal lineages in vitro, suggesting potential for use in regenerative therapies.

This study found that gene expression of CD70 and CD27 was higher in alopecia areata lesions and correlated with increased disease severity and activity.

This study concluded that in female pattern hair loss patients, CGF and i-PRF treatments were more effective than PRP in increasing target area hair count, with i-PRF having the lowest adverse event rate.

In this case study, a nine-year-old boy with alopecia universalis following severe chickenpox showed complete hair regrowth after treatment with tofacitinib, suggesting the drug's potential in managing varicella-zoster virus-induced alopecia by modulating immune responses.

In this study, a nanoparticle system codelivering diphenylcyclopropenone and rapamycin successfully induced immune tolerance and promoted hair regrowth in a mouse model of alopecia areata, offering a promising new therapeutic strategy for this autoimmune condition.

This study proposes that intranasal exposure to PTx and autoantigen in an animal model can trigger autoimmune disease, supporting the idea that subclinical nasal colonization by BP may cause alopecia areata.

In this study, researchers described protocols using C3H/HeJ mice to reliably induce alopecia areata through full-thickness skin grafts or adoptive transfer of cultured lymphoid cells, offering valuable models for studying the disease and testing new drug therapies.

In this study, researchers used single-cell RNA sequencing to identify cell types and molecular differences in subcutaneous adipose tissue from various anatomical sites, suggesting that certain subpopulations of human adipose stem cells might improve the treatment of chronic refractory wounds.

This study developed the Alopecia Areata Patient Priority Outcome (AAPPO), a new tool designed to measure and capture the symptoms and impacts of alopecia areata that matter most to patients.

In this study, researchers found that AP-2α and AP-2β are critical for maintaining epidermal homeostasis in adult skin, with their combined loss leading to severe skin and hair abnormalities and early skin inflammation due to impaired keratinocyte differentiation.

This review explores new theories, diagnostic tools, and management strategies for primary cicatricial alopecia but reports no new clinical findings.

This study suggests that DPCP treatment can be effective and safe for severe alopecia areata in children, with maintenance therapy potentially reducing relapse rates.

This study found that Paeonia lactiflora and Poria cocos extracts promoted hair regrowth in a mouse model of androgenetic alopecia, with similar effects observed to normal controls.

This study found that patients with primary cicatricial alopecia are at higher risk of developing various comorbidities, including systemic lupus erythematosus, hypothyroidism, and dermatological conditions, compared to controls.

This case study observed that a patient with multiple refractory inflammatory conditions, including psoriasis, alopecia areata, and psoriatic arthritis, experienced significant improvements after three months of treatment with upadacitinib. The report suggests potential benefits of upadacitinib for similar conditions, recommending further clinical trials.

This study demonstrated that an aloe polysaccharide-collagen wound dressing improved wound healing by enhancing angiogenesis and reducing inflammation in vivo.