Cells Derived From Concentrated Growth Factor Exhibit A Multilineage Differentiation Capacity

This study demonstrates that primary stem cells derived from concentrated growth factor (CGF) exhibit the ability to differentiate into multiple cell types, including adipocytes, endothelial cells, and neuronal-like cells, in vitro. The CGF primary cells (CPCs) were characterized by specific surface markers and stemness markers similar to human bone marrow mesenchymal stem cells (BMSCs). Following differentiation protocols, CPCs successfully acquired phenotypic and molecular markers specific to each lineage, such as lipid accumulation and gene upregulation in adipogenic differentiation, increased endothelial marker expression, and neuronal marker expression. The findings underscore the potential of CPCs in multilineage regenerative therapies due to their remarkable plasticity.