Curcumin Grafted Poly(Vinyl Alcohol) for Ascorbyl Palmitate Encapsulation

This study focused on encapsulating ascorbyl palmitate (AP) into curcumin-grafted poly(vinyl alcohol) (Cur-PV(OH)) and cinnamate-grafted poly(vinyl alcohol) (Cin-PV(OH)) nanoparticles. The encapsulated AP demonstrated greater stability compared to unencapsulated AP, with freeze-dried forms being more stable than suspension forms, and light-proof conditions enhancing stability. Cur-PV(OH) particles provided better stability for AP than Cin-PV(OH) particles, achieving an encapsulation efficiency of 80.85% and a loading of 29.00%. The average diameter of AP-loaded Cur-PV(OH) particles was 269.80 nm. A skin penetration study using pig ear skin revealed that hair follicles were the primary route for AP-Cur-PV(OH) particle penetration, with accumulated particles at hair follicles releasing AP into surrounding tissue.