Weathering The Storm: Harnessing The Resolution Of Inflammation To Limit COVID-19 Pathogenesis

The document reviewed the role of macrophages in inflammation and their potential in treating COVID-19 by highlighting their diverse phenotypes, particularly M1 and M2, which range from pro-inflammatory to pro-resolution states. It emphasized the importance of macrophage plasticity and phenotypic transitions in regulating inflammation and healing, suggesting that manipulating these transitions could influence immune responses. The study discussed the role of efferocytosis and macrophage reprogramming in resolving inflammation, particularly in preventing cytokine storms and severe COVID-19 symptoms. It also explored the potential of pro-resolving agents, such as annexin A1, and therapies like dexamethasone, in promoting inflammation resolution. The findings suggested that enhancing efferocytosis and specialized pro-resolving mediators could limit the severity of infection-associated cytokine storms, offering potential therapeutic strategies for managing COVID-19 and other inflammatory diseases.