AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis

    January 2024 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Hui Zhang, Jackelyn R. Raymundo, Kristian Daly … Alexander G. Marneros
    Studysummary In this study, researchers found that AP-2α and AP-2β are critical for maintaining epidermal homeostasis in adult skin, with their combined loss leading to severe skin and hair abnormalities and early skin inflammation due to impaired keratinocyte differentiation.
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    Research cited in this study 4

    1. Molecular and Spatial Landmarks of Early Mouse Skin Development Developmental cell · 2023
    2. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    3. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008
    4. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001

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