Diphenylcyclopropenone in Severe Alopecia Areata in Children and Adolescents: Long-Term Follow-Up and Relapse Rate

May 2024 in “ Journal of the Egyptian Womenʼs Dermatologic Society ”

Yasmin B. El Zawahry, Bakr M. El Zawahry, Dalia Ahmed Bassiouny, Ahmed Soliman, Heba Mohammed Abdel Raheem

diphenylcyclopropenone alopecia areata maintenance therapy DPCP AA

Studysummary This study suggests that DPCP treatment can be effective and safe for severe alopecia areata in children, with maintenance therapy potentially reducing relapse rates.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study assessed the long-term effectiveness and relapse rates of diphenylcyclopropenone (DPCP) in treating severe alopecia areata (AA) in 144 children and adolescents over 7 years. After 18 months, 65.8% achieved excellent hair regrowth, while 13.7% had moderate regrowth, and 20.5% showed poor response. Relapse rates were higher in those with more extensive disease, and 54.5% of excellent responders experienced relapse, particularly if maintenance therapy was discontinued. The study highlights DPCP as a promising treatment for severe AA in pediatric patients, emphasizing the importance of maintenance therapy to prevent relapse. Side effects were minimal, with severe irritation in 9.7% of patients.

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Research cited in this study

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research Five-Year Experience in the Treatment of Alopecia Areata with Diphencyprone

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