Alarmin Cytokines As Central Regulators Of Cutaneous Immunity
March 2022
in “
Frontiers in Immunology
”
alarmin cytokines TSLP IL-25 IL-33 cutaneous immunity epidermal keratinocytes immune cells host defense chronic inflammation atopic dermatitis dendritic cells Th2 cell differentiation IL-4 IL-5 IL-13 allergic skin inflammation wound healing tumor-associated macrophages tumor growth skin health skin disease therapeutic approaches allergic inflammation skin cancer skin immunity skin inflammation skin healing skin tumors skin therapy
TLDR Alarmin cytokines are key in controlling skin immunity and inflammation.
The document reviewed the role of type 2 alarmin cytokines, particularly TSLP, IL-25, and IL-33, in regulating cutaneous immunity. These cytokines were crucial in mediating communication between epidermal keratinocytes and immune cells, influencing host defense, chronic inflammation, and cancer. TSLP played a significant role in type 2 immune responses, particularly in conditions like atopic dermatitis, by activating dendritic cells and promoting Th2 cell differentiation. IL-25 was noted for inducing IL-4, IL-5, and IL-13 production, contributing to allergic skin inflammation and wound healing. IL-33 was implicated in allergic inflammation and tumor progression, recruiting tumor-associated macrophages and promoting tumor growth. The study highlighted the complex roles of these cytokines in skin health and disease, suggesting potential therapeutic approaches for allergic inflammation and skin cancer.
