Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases

May 2019 in “ Frontiers in Cell and Developmental Biology ”

Oindrila Bhattacharjee, Uttkarsh Ayyangar, Ambika S. Kurbet, Driti Ashok, S. Raghavan

extracellular matrix ECM skin diseases immune cell dynamics growth factors cytokines ECM organization ECM deposition skin pathologies ECM-immune cell interactions molecular components

TLDR Abnormal ECM and immune cell interactions can cause skin diseases.

The document discussed the role of the extracellular matrix (ECM) in skin diseases, highlighting its function beyond structural support to include dynamic remodeling for tissue homeostasis. The ECM interacted with cell surface receptors and regulated immune cell dynamics, acting as a reservoir for growth factors and cytokines. Dysregulation in ECM organization and deposition led to various skin pathologies, worsened by abnormal ECM-immune cell interactions. The review also covered advanced therapies targeting the molecular components involved in these processes.

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