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research 308 Epidermal keratinocytes regulate bacterial immune responses and host defense through EGFR

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study using a genetic mouse model found that S. aureus-driven dysbiosis sustains inflammatory skin side effects from EGFR inhibitors, suggesting prophylactic antibiotic treatment may reduce rash severity without fixing barrier defects.

research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17

32 citations , January 2024 in “The Journal of Experimental Medicine”

This study found that CXCL12+ fibroblast subsets in mouse skin play a critical role in recruiting neutrophils and defending against S. aureus infection, with similar fibroblast activity observed in human psoriatic skin.

research Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study observed that extracellular matrix scaffold membranes performed less effectively in wound healing for aged mice compared to younger ones, with senescent SPP1+ macrophages potentially hindering epidermal and fibroblast repair abilities.

research Alarmin Cytokines as Central Regulators of Cutaneous Immunity

51 citations , March 2022 in “Frontiers in Immunology”

This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.

research Biology of the skin and dermatological disease

7 citations , December 2004 in “Medicine”

This article reviews the anatomy and pathology of skin and hair to aid in diagnosing skin diseases and discusses potential therapies, without reporting new clinical results.

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Community Join

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community There is something off with DUT and it’s time we stop ignoring it

in Finasteride/Dutasteride 110 upvotes 1 year ago

Dutasteride and finasteride for hair loss, with dissatisfaction expressed about dutasteride and consideration of switching back to finasteride. Users share varied experiences, noting individual responses to treatments differ.

community UPDATE: now 5 months on Dut and continuing to regress aggressively

in Finasteride/Dutasteride 218 upvotes 1 year ago

The user is experiencing significant hair loss after switching from finasteride to dutasteride for five months. Suggestions include that the hair loss might be a normal shedding phase, with some recommending continuing the treatment for up to 24 months or considering alternatives like RU58841.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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