SARS-CoV-2-Induced Host Metabolic Reprogramming: Nutritional Interventions for Global Management of COVID-19 and Post-Acute Sequelae

The document discusses how SARS-CoV-2, the virus causing COVID-19, triggers a complex interaction in the human body leading to 'host metabolic reprogramming' (HMR), iron-redox dysregulation (FeRD), and altered mitochondrial function. These changes disrupt metabolic pathways involved in cellular energy and antioxidant enzyme function, compromising the body's innate defense. This can lead to new metabolic disorders, such as diabetes, and long-term health consequences in post-acute sequelae of COVID-19 (PASC). The most common long-term clinical manifestations of PASC include fatigue, headache, attention disorder, hair loss, and dyspnea. The review suggests that nutritional interventions, such as natural plant-based anti-inflammatories, immune-modulators, antioxidants, and macro-/micronutrient metabolic optimizers, can play a supportive role in managing PASC and the metabolic disorders and complications in COVID-19 survivors.