Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases
June 2021
in “
Frontiers in immunology
”
TLDR A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.
The document discusses the significant role of Thymic Stromal Lymphopoietin (TSLP), a cytokine protein, in various skin-related immune diseases. TSLP is found to be upregulated in patients with atopic dermatitis, psoriasis, bullous pemphigoid, systemic sclerosis, chronic spontaneous urticaria, Behcet's disease, vitiligo, and rosacea. It contributes to the elicitation of a T(H)2 response in atopic dermatitis, links keratinocytes and dendritic cell-derived IL-23 in psoriasis, induces profibrotic genes and intracellular signaling in systemic sclerosis, and is elevated in chronic spontaneous urticaria. In Behcet's disease, TSLP is implicated in the pathogenesis by dendritic cells, while in vitiligo, it is associated with the disease through the -847C>T polymorphism. In rosacea, TSLP expression is disturbed. These findings suggest TSLP could be a potential therapeutic target for these diseases.
