Interleukin-25 Mediated IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions
January 2022
in “
Frontiers in Immunology
”
Studysummary This study found that IL-25-mediated-IL-17RB signaling improved diabetic wound healing by enhancing angiogenesis, collagen deposition, and endothelial cell function, suggesting a potential therapeutic strategy for poorly healing diabetic wounds.
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The study explored the role of Interleukin-25 (IL-25) in enhancing wound healing in diabetic mice by improving endothelial cell functions. It was found that diabetic wounds had reduced IL-17RB expression, which correlated with impaired healing. Administering IL-25 improved wound healing by enhancing vascularization and collagen deposition, potentially through the activation of the AKT, ERK 1/2, and Wnt/β-catenin pathways. The study involved human skin samples from 18 patients and animal experiments with diabetic mice models, suggesting that IL-25-mediated-IL-17RB signaling could be a novel therapeutic target for treating impaired wound healing in diabetic patients.
