Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity

The study found that gene expression of CD70 and CD27 is significantly higher in alopecia areata (AA) lesions compared to non-lesional areas and healthy controls, with a strong correlation to disease severity and activity. This suggests that CD70 and CD27 can serve as predictors of AA severity and activity. Additionally, lower expression of these genes in non-lesional areas may predispose individuals to immunological dysregulation, contributing to the development of AA. The study involved 40 AA patients and 40 healthy controls.