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    Glossary AKT3

    gene involved in cell growth and survival

    AKT3 is a gene that encodes a protein involved in cell growth, survival, and metabolism. It is one of the three isoforms of the AKT kinase family, which play a crucial role in signaling pathways that regulate these cellular processes. Mutations or dysregulation of AKT3 can be associated with various conditions, including cancer and certain types of alopecia, where it may affect hair follicle function and growth.

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    1. Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos Journal of Cellular Physiology · 2019 · 7 citations
    2. News in brief Expert Review of Dermatology · 2011
    3. Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients Archives of Gynecology and Obstetrics · 2017 · 24 citations
    4. Akt2 and SGK3 are both determinants of postnatal hair follicle development The FASEB Journal · 2009 · 24 citations
    5. Efficacy and safety of platelet rich plasma therapy in male androgenetic alopecia Journal of Pakistan Association of Dermatology · 2020
    6. FOXO1, TGF-β Regulation and Wound Healing International Journal of Molecular Sciences · 2014 · 87 citations
    7. Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes Scientific Reports · 2017 · 54 citations
    8. Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland PLoS ONE · 2013 · 36 citations
    9. Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles Journal of Dermatological Science · 2013 · 27 citations
    10. Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment Scientific Reports · 2024 · 13 citations
    11. Biology of Human Hair: Know Your Hair to Control It 2010 · 13 citations
    12. Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model Tissue Engineering and Regenerative Medicine · 2024 · 9 citations
    13. Non-thermal plasma promotes hair growth by improving the inter-follicular macroenvironment RSC Advances · 2021 · 9 citations
    14. The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity PLoS ONE · 2022 · 6 citations
    15. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    16. Effects of Selenium and Other Micronutrient Intake on Human Health 2025
    17. AKT2 Gene Polymorphisms, sRANKL/OPG and Hormone Measurements in Polycystic Ovarian Syndrome (PCOS) Women Clinical & medical biochemistry · 2017
    18. Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism bioRxiv (Cold Spring Harbor Laboratory) · 2026
    19. Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism Archives of dermatological research · 2023 · 5 citations
    20. First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors Journal of clinical oncology · 2011 · 505 citations
    21. Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐catenin signalling Clinical and Translational Medicine · 2025
    22. Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy? Experimental Dermatology · 2006
    23. Abstract 4350: Pharmacodynamic biomarkers: Evaluation of oncology drug target engagement in human plucked scalp and beard hair Cancer Research · 2023
    24. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021 · 228 citations
    25. Cell death in the skin Apoptosis · 2009 · 120 citations
    26. Coronavirus Infection and Cholesterol Metabolism Frontiers in Immunology · 2022 · 55 citations
    27. Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype Frontiers in Genetics · 2022 · 37 citations
    28. Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells Medical Sciences · 2017 · 37 citations
    29. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    30. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations