Comparative Transcriptome Profiling of Hair Follicles from Forest Musk Deer at Different Stages
November 2022
in “
Research Square (Research Square)
”
hair follicle transcriptome differentially expressed genes anagen stage catagen stage ESR1 CAV1 FSTL1 TLR2 REM1 FGFR1 glycosaminoglycan binding proteins endocrine system cell development signaling pathways immune system gene expression growth phase regression phase estrogen receptor 1 caveolin 1 follistatin-like 1 toll-like receptor 2 radixin fibroblast growth factor receptor 1 GAG binding proteins hormonal system cell growth cell signaling immune response
TLDR The research provides insights into hair follicle growth in forest musk deer by identifying key genes and pathways involved.
The study sequenced the hair follicle transcriptome of 13 forest musk deer (FMD) to understand their growth and development. The sequencing resulted in 71,167 transcripts, with the longest being 101,907 bp and an N50 value of 4,942 bp. Researchers identified 219 differentially expressed genes (DEGs) between the anagen and catagen stages of hair follicles, with 10 up-regulated and 209 down-regulated genes in the anagen stage. Key hub genes such as ESR1, CAV1, FSTL1, TLR2, REM1, and FGFR1 were identified. The study found 31 significantly enriched KEGG pathways, including those related to glycosaminoglycan binding proteins and the endocrine system. The up-regulated genes were mostly associated with cell development and signaling pathways, while down-regulated genes were linked to diseases and the immune system. This research provides insights into the molecular regulation of hair follicle growth in FMD and may help future studies on diseases affecting captive FMD.
