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highly targeted anti-androgen that might have minimal systemic effects
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a synthetic estrogen used topically as an anti-androgen
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Frontline, gold standard treatment for combatting androgenic alopecia
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Research
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research Chromium supplementation does not improve weight loss or metabolic and hormonal variables in patients with polycystic ovary syndrome: A systematic review
Chromium supplements don't help with weight loss or improve hormone and metabolism issues in people with polycystic ovary syndrome.
research Hormonal Treatments in Hidradenitis Suppurativa: A Systematic Review
Hormonal treatments can effectively improve hidradenitis suppurativa symptoms.
research Efficacy Of Hormonal Therapy Vs Non-Hormonal Therapy in Female Pattern Hair Loss (FPHL): A Systematic Review
Both hormonal and non-hormonal therapies improve hair growth in women, but non-hormonal methods may be more effective with fewer side effects.
research Preoperative hormonal stimulation in hypospadias: a systematic review
Hormone treatment before hypospadias surgery can increase penis size and reduce surgery complications.
research Hormonal Regulation and Systemic Signals of Skin Aging
Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.
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community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?
Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.
community Anyone tried winlevi for hair loss? I am curious about it as someone who doesn’t want to change my hormones systemically.
Winlevi is being considered for hair loss by someone who wants to avoid systemic hormonal changes. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.
community A Technical Question About Pyrilutamide
Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.
community The expected timeline for PP405 - Next update at AAD Annual Meeting in March 2026 ?
A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.
community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors
Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.